Article Dans Une Revue Additive Manufacturing Année : 2023

Tuning pharmaceutically active zein-based formulations for additive manufacturing

Résumé

Zein, a biopolymer from corn, was plasticized by glycerol and an Active Pharmaceutical Ingredient-Ionic Liquid (API-IL) for its melt processing at 130 °C. In order to enhance the rheological properties of the formulation for 3D printing, the ratio of glycerol to API-IL was adjusted while maintaining a consistent addition of 20% plasticizer. A 50/50 ratio allowed obtaining an initial melt viscosity suitable for extrusion-based processes, at approximately 1 kPa.s at a shear rate of 10 s-1 , with a shear thinning behavior. This viscosity remained stable during a processing window of about 6 min, before zein proteins start to aggregate, leading to an apparent gelation phenomenon for long residence times. The processability of this formulation containing API-IL for the printing of tablets for potential therapeutic applications was confirmed by tests on a 3D printer. Nonetheless, in comparison to a reference formulation containing only glycerol, the printing accuracy experienced a decrease. This was ascribed to slower viscous sintering kinetics in presence of API-IL, evidenced by monitoring fusionbonding during dynamic X-ray tomography trials carried out at synchrotron SOLEIL.

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Dates et versions

hal-04274598 , version 1 (08-11-2023)

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Mélanie Thadasack, Anne-Laure Réguerre, Eric Leroy, Sofiane Guessasma, Denis Lourdin, et al.. Tuning pharmaceutically active zein-based formulations for additive manufacturing. Additive Manufacturing, 2023, 78, pp.103849. ⟨10.1016/j.addma.2023.103849⟩. ⟨hal-04274598⟩
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