Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2021

Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit

Résumé

Significance The mechanisms linking homeostatic regulation of synaptic transmission to homeostatic regulation of intrinsic excitability are poorly understood. We show here that chronic blockade of excitatory synaptic receptors in the CA3 area induces an up-regulation of both synaptic transmission and intrinsic excitability. Enhanced excitability was found to result from a reduction in Kv1.1 channel density at the axon initial segment. In parallel, enhanced synaptic transmission was largely due to a loss of presynaptic Kv1.1 function. We conclude that the regulation of axonal Kv1.1 channels constitutes a significant mechanism linking homeostatic regulation of synaptic transmission and homeostatic regulation of intrinsic excitability in CA3 circuits.

Domaines

Neurobiologie
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Dates et versions

hal-04272027 , version 1 (07-11-2023)

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Mickaël Zbili, Sylvain Rama, Maria-José Benitez, Laure Fronzaroli-Molinieres, Andrzej Bialowas, et al.. Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (47), pp.e2110601118. ⟨10.1073/pnas.2110601118⟩. ⟨hal-04272027⟩
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