Past and Future of Analog-Digital Modulation of Synaptic Transmission - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Frontiers in Cellular Neuroscience Année : 2019

Past and Future of Analog-Digital Modulation of Synaptic Transmission

Résumé

Action potentials (APs) are generally produced in response to complex summation of excitatory and inhibitory synaptic inputs. While it is usually considered as a digital event, both the amplitude and width of the AP are significantly impacted by the context of its emission. In particular, the analog variations in subthreshold membrane potential determine the spike waveform and subsequently affect synaptic strength, leading to the so-called analog-digital modulation of synaptic transmission. We review here the numerous evidence suggesting context-dependent modulation of spike waveform, the discovery analog-digital modulation of synaptic transmission in invertebrates and its recent validation in mammals. We discuss the potential roles of analog-digital transmission in the physiology of neural networks.

Domaines

Neurobiologie
Fichier principal
Vignette du fichier
fncel-13-00160.pdf (2.59 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04271999 , version 1 (24-05-2024)

Licence

Paternité

Identifiants

Citer

Mickael Zbili, Dominique Debanne. Past and Future of Analog-Digital Modulation of Synaptic Transmission. Frontiers in Cellular Neuroscience, 2019, 13, ⟨10.3389/fncel.2019.00160⟩. ⟨hal-04271999⟩
6 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More