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            <title xml:lang="en">Haemophilus influnezae ability to form biofilms may be linked to virulence in non-typable isolates</title>
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            <idno type="halRefHtml">&lt;i&gt;16th EMGM Congress&lt;/i&gt;, May 2023, Dubrovnick, Croatia. 2017</idno>
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                <title xml:lang="en">Haemophilus influnezae ability to form biofilms may be linked to virulence in non-typable isolates</title>
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                  <persName>
                    <forename type="first">Nouria</forename>
                    <surname>Belkacem</surname>
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                    <forename type="first">Ala-Eddine</forename>
                    <surname>Deghmane</surname>
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                  <title>16th EMGM Congress</title>
                  <date type="start">2023-05-29</date>
                  <date type="end">2023-06-01</date>
                  <settlement>Dubrovnick</settlement>
                  <country key="HR">Croatia</country>
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                  <name>European Meningococcal and Haemophilus Disease Society</name>
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                  <date type="datePub">2017</date>
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              <classCode scheme="halOldTypology" n="POSTER">Poster communications</classCode>
              <classCode scheme="halTreeTypology" n="POSTER">Poster communications</classCode>
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              <p>IntroductionNon-typeable Haemophilus Influenzae (NTHi) is responsible for invasive infections that are encountered frequently in older adults but encountered in all age groups. Biofilms represent a protective mechanism that enhances bacterial resistance to clearance. Biofilm formation by Hi has been studied in only a limited number of strains, and a repertoire of genes and bacterial surface structures have been implicated in biofilm formation and maturation. These include type IV pili over-expression, the presence of fimbriae, quorum sensing, the presence of outer membrane proteins P2 and P5, and the presence of phosphorylcholine and sialic acid in the lipooligosaccharide molecule.AimTo understand the relationship between biofilm formation and virulence.Materials and MethodsWe analyzed the ability of NTHi and typeable isolates to form biofilms using plate assay with crystal violet staining. WGS was used to characterize Hi according to schemes of genes involved in biofilm formation.ResultsInvasive NTHi isolates trend towards higher biofilm indices than invasive typeable isolates regardless of age or clinical forms.ConclusionsNTHi isolates lack capsule and biofilm formation may enhance NTHi survival upon acquisition and contribute to bacterial growth and invasiveness.</p>
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