A seven step sequential extraction procedure has been conducted on a podzolic soil profile from the Vosges Mountains in order to determine the ability of several elements to be released to the environment. Very little Si, K and Al were extractable (< 10% of the total soil concentration) but larger proportions (> 10% of the total soil concentration) of Ca, P, metals (Fe, Pb), REE and actinides (Th, U) could be leached. For each element, preferential binding sites can be recognized. High recovery of P and Ca in the acid soluble fraction (AS) suggests that phosphate minerals are highly involved in this step of the extraction. Organic matter appears to control the adsorption of Ca, Fe, Th, U and REE, even at depths in the soil profile where organic matter content is particularly low (0.5%). Weak acid leaching experiments (with HCl and acid acetic 0.001 N) were also performed in order to characterize the origin of the insoluble material in this soil profile. The leachable REE distributions indicate that a large part of the labile REE in the surface horizon has an atmospheric origin whereas at greater depth phosphate mineral (apatite) alteration is the main factor controlling REE release in the leachate. Our study further suggests that adsorbed material holding actinides and REE are not strictly the same. So, caution should be taken when using REE as analogues for actinides in soils systems.