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Poster De Conférence Année : 2023

NMR Metabolomics Profiling Reveals Distinctive Signatures of an Obesogenic Diet in Mice

Résumé

Obesity is a significant risk factor for diseases like type 2 diabetes and cardiovascular disorders. Identifying biomarkers for early obesity-related disorders is crucial for precision medicine. We used NMR to analyze metabolomic profiles of key organs and serum in male C57Bl/6J mice fed a high-fat, high-sucrose diet (HFHSD, 36 % w/w fat, 16.6 % w/w sucrose, Envigo, France) or standard diet (STD, Rhod16A, Genobio) for 6, 10, and 14 weeks. Our study reveals organ-specific metabolite concentrations, highlighting age and diet effects and their interaction.
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Dates et versions

hal-04265181 , version 1 (31-10-2023)

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  • HAL Id : hal-04265181 , version 1

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Eva Drevet Mulard, Sylvie Guibert, C. Lefevre, M.A. Chauvin, Claudie Pinteur, et al.. NMR Metabolomics Profiling Reveals Distinctive Signatures of an Obesogenic Diet in Mice: Uncovering Metabolite Signatures in Six Organs During a High-Fat, High-Sucrose Diet: A Cross-Sectional NMR Metabolomics Study. 15èmes journées scientifiques du Réseau Francophone de Métabolomique et Fluxomique (RFMF), May 2023, Perpignan, France. ⟨hal-04265181⟩
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