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Article Dans Une Revue Frontiers in Psychiatry Année : 2023

A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment

Résumé

Crack-cocaine dependence is a severe condition with a high mortality rate. This single case study report details the first deep brain stimulation (DBS) trial targeting the sub-thalamic nucleus (STN) for crack-cocaine dependence. The investigation aimed to assess the effects of STN-DBS on cocaine craving and cocaine use, as well as STN-DBS safety and tolerance in this indication. In this pilot study, we performed double blind cross-over trials, with “ON-DBS” vs. “SHAM-DBS” for 1-month periods. STN-DBS failed to reduce cocaine craving and use. An episode of DBS-induced hypomania occurred after several weeks of cocaine intake at stimulation parameters previously well tolerated. Future research on cocaine dependence should be conducted after a prolonged abstinence period and/or explore novel types of stimulation patterns.
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Dates et versions

hal-04262862 , version 1 (27-10-2023)

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Florence Vorspan, Philippe Domenech, David Grabli, Jérôme Yelnik, Marine Delavest, et al.. A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment. Frontiers in Psychiatry, 2023, 14, pp.1146492. ⟨10.3389/fpsyt.2023.1146492⟩. ⟨hal-04262862⟩
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