Cobalt-Catalyzed Reductive Cross-Coupling To Construct Csp 3 –Csp 3 Bonds via Csp 3 –S and Csp 3 –X Bonds Activation
Résumé
A cross-electrophilic coupling of benzyl sulfonium salts with alkyl halides forming Csp3-Csp3 bonds is described using a Co-based catalytic system. The activation of the stable Csp3-S bond of benzyl sulfonium salts under mild reaction conditions leads to various functionalized alkyl derivatives.
Preliminary mechanistic studies suggest the involvement of alkyl radicals both formed from alkyl halides and benzyl sulfoniums through a single electron transfer.
Domaines
Chimie
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Csp3-Csp3 bond wirh alkyl -I sept 14th -MG (1).pdf (1.24 Mo)
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