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Pré-Publication, Document De Travail Année : 2023

Tilt-induced clustering of cell adhesion proteins

Résumé

Cell adhesion proteins are transmembrane proteins that bind cells to their environment. These proteins typically cluster into disk-shaped or linear structures. Here we show that such clustering patterns spontaneously emerge when the protein sense the membrane deformation gradient, for example by reaching a lower-energy conformation when the membrane is tilted relative to the underlying binding substrate. Increasing the strength of the membrane gradient-sensing mechanism first yields isolated disk-shaped clusters and then long linear structures. Our theory is coherent with experimental estimates, suggesting that a tilt-induced clustering mechanism is relevant in the context of cell adhesion proteins.
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Dates et versions

hal-04261841 , version 1 (27-10-2023)

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Shao-Zhen Lin, Rishita Changede, Michael Sheetz, Jacques Prost, Jean-Francois Rupprecht. Tilt-induced clustering of cell adhesion proteins. 2023. ⟨hal-04261841⟩
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