Article Dans Une Revue Allergy Année : 2021

Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model

1 ASST Pini-CTO
2 Kuwait University
3 Al-Rashed Allergy Center [Kuwait City]
4 Hospital Quirónsalud Bizkaia [Bilbao]
5 IRCCS Ospedale Pediatrico Bambino Gesù = Bambino Gesù Children’s Hospital
6 Ghent University Hospital
7 Karolinska Institutet = Karolinska Institute [Stockholm]
8 Karolinska University Hospital [Stockholm]
9 Stallergenes - Stallergenes SA
10 CHU Montpellier = Montpellier University Hospital
11 MACVIA-LR - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
12 SUM - Medical University of Silesia
13 Hôpital Arnaud de Villeneuve [CHU Montpellier]
14 IDESP - Institut Desbrest d'Epidémiologie et de Santé Publique
15 Imperial College London
16 USF - University of South Florida [Tampa]
17 University of Manchester [Manchester]
18 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
19 EPAR - Epidemiology of Allergic and Respiratory Diseases Department [iPlesp]
20 Hôpital Foch [Suresnes]
21 Université Paris-Saclay
22 Pôle Clinique des Voies respiratoires [CHU Toulouse]
23 Guy's and St Thomas' Hospitals
24 Humanitas Clinical and Research Center [Rozzano, Milan, Italy]
25 Hunimed - Humanitas University [Milan]
26 Federal Institute of Immunology of Russia [Moscou]
27 USJ - Université Saint-Joseph de Beyrouth / Saint Joseph University of Beirut
28 Wrocław Medical University
29 Center for Rhinology and Allergology = Zentrum für Rhinologie und Allergologie
30 MUL - Medical University of Łódź
31 Monash University [Melbourne]
32 Federal Medical-Biological Agency of Russia
33 Charité - UniversitätsMedizin = Berlin University Medicine
34 Hospital CUF Descobertas
35 Universität zu Köln = University of Cologne
36 Clinical Research International Ltd.
37 University Hospital Bonn
38 Chiba University Hospital
39 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] = Université Charles [Prague, Republique tchèque]
40 NKUA - National and Kapodistrian University of Athens
41 Ajou University School of Medicine
42 UniGe - Università degli studi di Genova = University of Genoa = Université de Gênes
43 Nippon Medical School [Tokyo, Japon]
44 Philipps Universität Marburg = Philipps University of Marburg
45 University hospital of Zurich [Zurich]
46 Dr Peset University Hospital
47 UV - Universitat de València = University of Valencia = Universidade de Valencia
48 CHUS - Complejo Hospitalario Universitario de Santiago de Compostela [ESpaña] = USC University Hospital Complex [Spain] = Centre hospitalier universitaire de Saint-Jacques-de-Compostelle [Espagne]
49 University of Rostock = Universität Rostock
Cristoforo Incorvaia
Andrzéj Bozek
Philippe Gevaert
Maximiliano Gomez
  • Fonction : Auteur
Marek Jutel
Piotr Kuna
Mario Morais‐almeida
Hae‐sim Park
Ruby Pawankar
Petra Zieglmayer
  • Fonction : Auteur

Résumé

The introduction of personalized medicine (PM) has been a milestone in the history of medical therapy, because it has revolutionized the previous approach of treating the disease with that of treating the patient. It is known today that diseases can occur in different genetic variants, making specific treatments of proven efficacy necessary for a given endotype. Allergic diseases are particularly suitable for PM, because they meet the therapeutic success requirements, including a known molecular mechanism of the disease, a diagnostic tool for such disease, and a treatment blocking the mechanism. The stakes of PM in allergic patients are molecular diagnostics, to detect specific IgE to single-allergen molecules and to distinguish the causative molecules from those merely cross-reactive, pursuit of patient's treatable traits addressing genetic, phenotypic, and psychosocial features, and omics, such as proteomics, epi-genomics, metabolomics, and breathomics, to forecast patient's responsiveness to therapies, to detect biomarker and mediators, and to verify the disease control. This new approach has already improved the precision of allergy diagnosis and is likely to significantly increase, through the higher performance achieved with the personalized treatment, the effectiveness of allergen immunotherapy by enhancing its already known and unique characteristics of treatment that acts on the causes.

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hal-03613250 , version 1 (23-03-2022)

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Cristoforo Incorvaia, Mona Al‐ahmad, Ignacio Ansotegui, Stefania Arasi, Claus Bachert, et al.. Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model. Allergy, 2021, 76 (4), pp.1041-1052. ⟨10.1111/all.14575⟩. ⟨hal-03613250⟩
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