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Article Dans Une Revue Biomechanics and Modeling in Mechanobiology Année : 2023

In silico analysis shows that dynamic changes in curvature guide cell migration over long distances

Une analyse in silico montre que les changements dynamiques de courbure guident la migration cellulaire sur de grandes distances.

Résumé

In-vitro experiments have shown that cell scale curvatures influence cell migration; cells avoid convex hills and settle in concave valleys. However, it is not known whether dynamic changes in curvature can guide cell migration. This study extends a previous in-silico model to explore the effects over time of changing the substrate curvature on cell migration guidance. By simulating a dynamic surface curvature using traveling wave patterns, we investigate the influence of wave height and speed, and find that long-distance cell migration guidance can be achieved on specific wave patterns. We propose a mechanistic explanation of what we call dynamic curvotaxis and highlight those cellular features that may be involved. Our results open a new area of study for understanding cell mobility in dynamic environments, from single-cell in-vitro experiments to multi-cellular in-vivo mechanisms.
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Licence : CC BY - Paternité
Origine : Fichiers produits par l'(les) auteur(s)
Licence : Domaine public

Dates et versions

hal-04258011 , version 1 (26-10-2023)

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Paternité

Identifiants

Citer

Ian Manifacier, Gildas Carlin, Dongshu Liu, Maxime Vassaux, Laurent Pieuchot, et al.. In silico analysis shows that dynamic changes in curvature guide cell migration over long distances. Biomechanics and Modeling in Mechanobiology, 2023, ⟨10.1007/s10237-023-01777-4⟩. ⟨hal-04258011⟩
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