In silico analysis shows that dynamic changes in curvature guide cell migration over long distances
Une analyse in silico montre que les changements dynamiques de courbure guident la migration cellulaire sur de grandes distances.
Résumé
In-vitro experiments have shown that cell scale curvatures influence cell migration; cells avoid convex hills and settle in concave valleys. However, it is not known whether dynamic changes in curvature can guide cell migration. This study extends a previous in-silico model to explore the effects over time of changing the substrate curvature on cell migration guidance. By simulating a dynamic surface curvature using traveling wave patterns, we investigate the influence of wave height and speed, and find that long-distance cell migration guidance can be achieved on specific wave patterns. We propose a mechanistic explanation of what we call dynamic curvotaxis and highlight those cellular features that may be involved. Our results open a new area of study for understanding cell mobility in dynamic environments, from single-cell in-vitro experiments to multi-cellular in-vivo mechanisms.
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ManifacierCarlinMilan2023.pdf (1.13 Mo)
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JL_Milan_Revised_Manuscript_Phase2_8sept2023_accepted_modifications_sans_numero_lignes (1).pdf (1.13 Mo)
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