Combinatorial Screening of Water/Proton Permeation of Self‐Assembled Pillar[5]arene Artificial Water Channel Libraries - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Angewandte Chemie International Edition Année : 2023

Combinatorial Screening of Water/Proton Permeation of Self‐Assembled Pillar[5]arene Artificial Water Channel Libraries

Shixin Fa
  • Fonction : Auteur
Marc Baaden
Tomoki Ogoshi
  • Fonction : Auteur
  • PersonId : 1083309
Mihail Barboiu

Résumé

Artificial water channels (AWCs) that selectively transport water and reject ions through bilayer membranes have potential to act as synthetic Aquaporins (AQPs). AWCs can have a similar osmotic permeability, better stability, with simpler manufacture on a larger‐scale and have higher functional density and surface permeability when inserted into the membrane. Here, we report the screening of combinatorial libraries of symmetrical and unsymmetrical rim‐functionalized PAs A – D that are able to transport ca. 10 7 –10 8 water molecules/s/channel, which is within 1 order of magnitude of AQPs’ and show total ion and proton rejection. Among the four channels, C and D are 3–4 times more water permeable than A and B when inserted in bilayer membranes. The binary combinations of A – D with different molar ratios could be expressed as an independent (linear ABA ), a recessive (inhibition AB , AC , DB , ACA ), or a dominant (amplification, DBD ) behavior of the water net permeation events.

Domaines

Génie chimique
Fichier principal
Vignette du fichier
PA-paper_R2.pdf (283.26 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04257786 , version 1 (25-10-2023)

Identifiants

Citer

Iuliana‐marilena Andrei, Dmytro Strilets, Shixin Fa, Marc Baaden, Tomoki Ogoshi, et al.. Combinatorial Screening of Water/Proton Permeation of Self‐Assembled Pillar[5]arene Artificial Water Channel Libraries. Angewandte Chemie International Edition, 2023, 62 (42), pp.e202310812. ⟨10.1002/anie.202310812⟩. ⟨hal-04257786⟩
11 Consultations
9 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More