The fourth industrial revolution aims to achieve greater flexibility and adaptability in manufacturing systems through the use of information and communication technologies. The Digital Twin technology has emerged as a promising solution to support human-centered decision-making in this context. Despite growing interest in this area, there is still a lack of applications that integrate decision-support functionality and emphasize the relationship between real-time Digital Twin models and what-if simulation models. Hence, this paper discusses the integration of simulation models into a Digital Twin architecture to assist operators in making appropriate decisions. A proof of concept is presented to demonstrate this approach's feasibility and open up perspectives for further research in this area.