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Communication Dans Un Congrès Année : 2022

Modelling interactions between host and gut microbiota.

Résumé

Intestinal host-microbiota interactions form a symbiosis mainly regulated at the intestinal crypt level. These crosstalks play a major role in ensuring the health of the host. Modelling these interactions is a further step to understand the behaviour of this ecosystem and determine whether healthy states can be recovered after a deterioration of the host-microbiota symbiosis. Using a crypt model structured in space and cell types proposed in [1], we added new components such as inflammatory response at the epithelial cells scale, mucus production and degradation as well as the presence of different bacterial families (strict or facultative anaerobic, mucus degrader, pathobiont) inspired from [2]. We investigate if this model is able to simulate switches from healthy host-microbiota interactions to chronic inflammation. 1] L. Darrigade et al. A pdmp model of the epithelial cell turn-over in the intestinal crypt including microbiota-derived regulations. HAL, 2021. [2] R. Muñoz-Tamayo et al. Mathematical modelling of carbohydrate degradation by human colonic microbiota. Journal of theoretical biology, 2010.
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hal-04249173 , version 1 (19-10-2023)

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  • HAL Id : hal-04249173 , version 1

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Marie Haghebaert, Béatrice Laroche. Modelling interactions between host and gut microbiota.. ECMTB 2022 - European Conference on Mathematical and Theoretical Biology, Sep 2022, Heidelberg, Germany. ⟨hal-04249173⟩
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