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Journal Articles Nature Communications Year : 2023

HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria

Cyril Planchais
  • Function : Author
  • PersonId : 1296576
Thierry Hieu
Jordan D Dimitrov

Abstract

Abstract HIV-1 infection causes severe alterations of gut mucosa, microbiota and immune system, which can be curbed by early antiretroviral therapy. Here, we investigate how treatment timing affects intestinal memory B-cell and plasmablast repertoires of HIV-1-infected humans. We show that only class-switched memory B cells markedly differ between subjects treated during the acute and chronic phases of infection. Intestinal memory B-cell monoclonal antibodies show more prevalent polyreactive and commensal bacteria-reactive clones in late- compared to early-treated individuals. Mirroring this, serum IgA polyreactivity and commensal-reactivity are strongly increased in late-treated individuals and correlate with intestinal permeability and systemic inflammatory markers. Polyreactive blood IgA memory B cells, many of which egressed from the gut, are also substantially enriched in late-treated individuals. Our data establish gut and systemic B-cell polyreactivity to commensal bacteria as hallmarks of chronic HIV-1 infection and suggest that initiating treatment early may limit intestinal B-cell abnormalities compromising HIV-1 humoral response.
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hal-04248132 , version 1 (18-10-2023)

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Cyril Planchais, Luis M Molinos-Albert, Pierre Rosenbaum, Thierry Hieu, Alexia Kanyavuz, et al.. HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria. Nature Communications, 2023, 14 (1), pp.6326. ⟨10.1038/s41467-023-42027-6⟩. ⟨hal-04248132⟩
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