The leaderless communication peptide (LCP) class of quorum-sensing peptides is broadly distributed among Firmicutes - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2023

The leaderless communication peptide (LCP) class of quorum-sensing peptides is broadly distributed among Firmicutes

Shifu Aggarwal
  • Fonction : Auteur
Elaine Huang
  • Fonction : Auteur
Hackwon Do
  • Fonction : Auteur
Nishanth Makthal
  • Fonction : Auteur
Yanyan Li
Charles Bernard
Muthiah Kumaraswami

Résumé

Abstract The human pathogen Streptococcus pyogenes secretes a short peptide (leaderless communication peptide, LCP) that mediates intercellular communication and controls bacterial virulence through interaction with its receptor, RopB. Here, we show that LCP and RopB homologues are present in other Firmicutes. We experimentally validate that LCPs with distinct peptide communication codes act as bacterial intercellular signals and regulate gene expression in Streptococcus salivarius , Streptococcus porcinus , Enterococcus malodoratus and Limosilactobacillus reuteri . Our results indicate that LCPs are more widespread than previously thought, and their characterization may uncover new signaling mechanisms and roles in coordinating diverse bacterial traits.
Fichier principal
Vignette du fichier
s41467-023-41719-3.pdf (2.73 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04247659 , version 1 (18-10-2023)

Identifiants

Citer

Shifu Aggarwal, Elaine Huang, Hackwon Do, Nishanth Makthal, Yanyan Li, et al.. The leaderless communication peptide (LCP) class of quorum-sensing peptides is broadly distributed among Firmicutes. Nature Communications, 2023, 14 (1), pp.5947. ⟨10.1038/s41467-023-41719-3⟩. ⟨hal-04247659⟩
52 Consultations
27 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More