Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics
Résumé
Highlights d Nav1.6 mediates I NaP and self-sustained spiking activity in bistable motoneurons d Silencing Nav1.6 in spinal motoneurons alters posture and locomotor performance d Nav1.6 works with Nav1.1 to mediate I NaP and bursting pacemakers within locomotor CPG d The Nav1.1-Nav1.6 partnership generates the locomotor rhythm Authors Benoît Drouillas, Ce ´cile Brocard, Se ´bastien Zanella, Re ´mi Bos, Fre ´de ´ric Brocard
Domaines
Sciences du Vivant [q-bio]Origine | Fichiers éditeurs autorisés sur une archive ouverte |
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