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Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2023

A mechanosensitive vascular niche for Drosophila hematopoiesis

Abstract

Hematopoietic stem and progenitor cells maintain blood cell homeostasis by integrating various cues provided by specialized microenvironments or niches. Biomechanical forces are emerging as key regulators of hematopoiesis. Here, we report that mechanical stimuli provided by blood flow in the vascular niche control Drosophila hematopoiesis. In vascular niche cells, the mechanosensitive channel Piezo transduces mechanical forces through intracellular calcium upregulation, leading to Notch activation and repression of FGF ligand transcription, known to regulate hematopoietic progenitor maintenance. Our results provide insight into how the vascular niche integrates mechanical stimuli to regulate hematopoiesis.
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Origin : Publication funded by an institution
Licence : Public Domain

Dates and versions

hal-04244040 , version 1 (16-10-2023)

Identifiers

  • HAL Id : hal-04244040 , version 1

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Yushun Tian, Ismaël Morin-Poulard, Xiaohui Liu, Nathalie Vanzo, Michèle Crozatier. A mechanosensitive vascular niche for Drosophila hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (18), pp.e2217862120. ⟨hal-04244040⟩
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