Liver‐Expressed Antimicrobial Peptide 2 antagonizes the insulinostatic effect of ghrelin in rat isolated pancreatic islets - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Fundamental & Clinical Pharmacology Année : 2022

Liver‐Expressed Antimicrobial Peptide 2 antagonizes the insulinostatic effect of ghrelin in rat isolated pancreatic islets

Résumé

The hormone ghrelin is the endogenous agonist of the G protein‐coupled receptor (GPCR) termed growth hormone secretagogue receptor (GHSR). Ghrelin inhibits glucose‐stimulated insulin secretion by activating pancreatic GHSR. Recently, Liver‐Expressed Antimicrobial Peptide 2 (LEAP2) was recognized as an endogenous GHSR ligand that blocks ghrelin‐induced actions. Nonetheless, the effect of LEAP2 on glucose‐stimulated insulin secretion from pancreatic islets is unknown. We aimed at exploring the activity of LEAP2 on glucose‐stimulated insulin secretion. Islets of Langerhans isolated from rat pancreas were exposed to glucose in the presence or in the absence of LEAP2 and ghrelin and then insulin secretion was assayed. LEAP2 did not modulate glucose‐stimulated insulin secretion. However, LEAP2 blocked the insulinostatic action of ghrelin. Our data show that LEAP2 behaves as an antagonist of pancreatic GHSR.
Fichier principal
Vignette du fichier
Revised Bayle et al LEAP2 and insulin secretion(3).pdf (317.25 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04244032 , version 1 (16-10-2023)

Identifiants

Citer

Morgane Bayle, Sylvie Roux, Guillaume Gautheron, Gérard Cros, Catherine Oiry, et al.. Liver‐Expressed Antimicrobial Peptide 2 antagonizes the insulinostatic effect of ghrelin in rat isolated pancreatic islets. Fundamental & Clinical Pharmacology, 2022, 36 (2), pp.375-377. ⟨10.1111/fcp.12722⟩. ⟨hal-04244032⟩
76 Consultations
169 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More