Solvation in deep eutectic solvents (DESs) and encapsulation in macrocycles are efficient strategies for molecule's solubilization. Recently, new systems combining DES and macrocycles are being constructed using two approaches: a) solubilizing hosts in preformed DES or b) using hosts as a DES component. This strategy could evolve in new outcomes in DES properties, more precisely provide the solvents with supramolecular capacity, and translate into interesting performances. In the present review, we will give the reader an overview of the studies accomplished in this growing research area, with a focus on the experimental perspectives that we consider to be the most important in order to enlarge knowledge on the properties and behavior of these neoteric systems.