Cross-regulation and cross-talk of conserved and accessory two-component regulatory systems orchestrate<i>Pseudomonas</i>copper resistance - Archive ouverte HAL Accéder directement au contenu
Pré-Publication, Document De Travail Année : 2023

Cross-regulation and cross-talk of conserved and accessory two-component regulatory systems orchestratePseudomonascopper resistance

Résumé

Bacteria use diverse strategies and molecular machinery to maintain copper homeostasis and to cope with its toxic effects. Some genetic elements providing copper resistance are acquired by horizontal gene transfer; however, little is known about how they are controlled and integrated into the central regulatory network. Here, we studied two copper-responsive systems in a clinical isolate of Pseudomonas paraeruginosa and deciphered the regulatory and cross-regulation mechanisms. To do so, we combined mutagenesis, .
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hal-04239416 , version 1 (12-10-2023)

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Sylvie Elsen, Victor Simon, Ina Attrée. Cross-regulation and cross-talk of conserved and accessory two-component regulatory systems orchestratePseudomonascopper resistance. 2023. ⟨hal-04239416⟩
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