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Article Dans Une Revue Molecular Cancer Année : 2023

TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2

André Baruchel
  • Fonction : Auteur

Résumé

The reintegration of excised signal joints resulting from human V(D)J recombination was described as a potent source of genomic instability in human lymphoid cancers. However, such molecular events have not been recurrently reported in clinical patient lymphoma/leukemia samples. Using a specifically designed NGS-capture pipeline, we here demonstrated the reintegration of T-cell receptor excision circles (TRECs) in 20/1533 (1.3%) patients with T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). Remarkably, the reintegration of TREC recurrently targeted the tumor suppressor gene, ZFP36L2, in 17/20 samples. Thus, our data identified a new and hardly detectable mechanism of gene deregulation in lymphoid cancers providing new insights in human oncogenesis.
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Dates et versions

hal-04237392 , version 1 (11-10-2023)

Identifiants

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Estelle Balducci, Thomas Steimlé, Charlotte Smith, Patrick Villarese, Mélanie Feroul, et al.. TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2. Molecular Cancer, 2023, 22 (1), pp.108. ⟨10.1186/s12943-023-01794-y⟩. ⟨hal-04237392⟩
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