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Poster De Conférence Année : 2016

Proliferation impairment of chondrosarcoma cells irradiated with X-Rays and carbon-ion beams

Résumé

Chondrosarcoma is a malignant tumor arising from cartilaginous tissues, described as radiation- and chemo- resistant to conventional treatments. The primary treatment consists in wide surgical resection, which may lead to severe disabilities; in addition, this procedure is not feasible for some inoperable locations such as skull base chondrosarcoma. Carbon-ion irradiation (hadron-therapy) has been successfully used in the treatment of chondrosarcoma, due notably to a higher biological effectiveness and a better ballistic as compared with conventional radiotherapy with X-Rays. Aim of this study - explore the differential cellular responses of chondrosarcomas to conventional radiotherapy and hadrontherapy - understand the biological effects of carbon beams in cancer treatment. - estimate the capacity of PARP-1 inhibitor in radio-sensitizing chondrosarcoma cells
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Dates et versions

hal-04236718 , version 1 (16-10-2023)

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  • HAL Id : hal-04236718 , version 1

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François Chevalier, Dounia Houria Hamdi, Yvonne De Jong, Judith V. M. G.. Bovée, Yannick Saintigny. Proliferation impairment of chondrosarcoma cells irradiated with X-Rays and carbon-ion beams. PTCOG55 2016 - the 55th Annual Meeting for the Particle Therapy Cooperative Group, May 2016, Prague, Czech Republic. . ⟨hal-04236718⟩
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