Proliferation impairment of chondrosarcoma cells irradiated with X-Rays and carbon-ion beams
Résumé
Chondrosarcoma is a malignant tumor arising from cartilaginous tissues, described as radiation- and chemo- resistant to conventional treatments.
The primary treatment consists in wide surgical resection, which may lead to severe disabilities; in addition, this procedure is not feasible for some inoperable locations such as skull base chondrosarcoma.
Carbon-ion irradiation (hadron-therapy) has been successfully used in the treatment of chondrosarcoma, due notably to a higher biological effectiveness and a better ballistic as compared with conventional radiotherapy with X-Rays.
Aim of this study
- explore the differential cellular responses of chondrosarcomas to conventional radiotherapy and hadrontherapy
- understand the biological effects of carbon beams in cancer treatment.
- estimate the capacity of PARP-1 inhibitor in radio-sensitizing chondrosarcoma cells