Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue BMC Neurology Année : 2023

Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy?

Gautier Breville
  • Fonction : Auteur
François Herrmann
  • Fonction : Auteur
Dan Adler
  • Fonction : Auteur
Christine Deffert
  • Fonction : Auteur
Giulia Bommarito
  • Fonction : Auteur
Patrick Stancu
  • Fonction : Auteur
Alice Accorroni
  • Fonction : Auteur
Marjolaine Uginet
  • Fonction : Auteur
Frederic Assal
  • Fonction : Auteur
Patrice Lalive
  • Fonction : Auteur
Karl-Olof Lövblad
  • Fonction : Auteur
Gilles Allali
  • Fonction : Auteur

Résumé

Abstract Background This study evaluates the impact of high risk of obstructive sleep apnea (OSA) on coronavirus disease 2019 (COVID-19) acute encephalopathy (AE). Methods Between 3/1/2020 and 11/1/2021, 97 consecutive patients were evaluated at the Geneva University Hospitals with a neurological diagnosis of COVID-19 AE. They were divided in two groups depending on the presence or absence of high risk for OSA based on the modified NOSAS score (mNOSAS, respectively ≥ 8 and < 8). We compared patients’ characteristics (clinical, biological, brain MRI, EEG, pulmonary CT). The severity of COVID-19 AE relied on the RASS and CAM scores. Results Most COVID-19 AE patients presented with a high mNOSAS, suggesting high risk of OSA (> 80%). Patients with a high mNOSAS had a more severe form of COVID-19 AE (84.8% versus 27.8%), longer mean duration of COVID-19 AE (27.9 versus 16.9 days), higher mRS at discharge (≥ 3 in 58.2% versus 16.7%), and increased prevalence of brain vessels enhancement (98.1% versus 20.0%). High risk of OSA was associated with a 14 fold increased risk of developing a severe COVID-19 AE (OR = 14.52). Discussion These observations suggest an association between high risk of OSA and COVID-19 AE severity. High risk of OSA could be a predisposing factor leading to severe COVID-19 AE and consecutive long-term sequalae.

Dates et versions

hal-04235354 , version 1 (10-10-2023)

Identifiants

Citer

Gautier Breville, François Herrmann, Dan Adler, Christine Deffert, Giulia Bommarito, et al.. Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy?. BMC Neurology, 2023, 23 (1), pp.340. ⟨10.1186/s12883-023-03393-2⟩. ⟨hal-04235354⟩

Collections

UGA
20 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More