<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04234855</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-21T12:04:36+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Severe COVID-19 patients have impaired plasmacytoid dendritic cell-mediated control of SARS-CoV-2</title>
            <author role="aut">
              <persName>
                <forename type="first">Manon</forename>
                <surname>Venet</surname>
              </persName>
              <idno type="idhal" notation="numeric">1292207</idno>
              <idno type="halauthorid" notation="string">2917295-1292207</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5065-8463</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-1073351"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Margarida Sa</forename>
                <surname>Ribeiro</surname>
              </persName>
              <idno type="idhal" notation="numeric">1292208</idno>
              <idno type="halauthorid" notation="string">2917296-1292208</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4768-9728</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-1073351"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elodie</forename>
                <surname>Décembre</surname>
              </persName>
              <idno type="idhal" notation="numeric">1189897</idno>
              <idno type="halauthorid" notation="string">867618-1189897</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6891-6320</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-1073351"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alicia</forename>
                <surname>Bellomo</surname>
              </persName>
              <idno type="halauthorid">2053585-0</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-1073351"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Garima</forename>
                <surname>Joshi</surname>
              </persName>
              <idno type="halauthorid">2917297-0</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-1073351"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Célia</forename>
                <surname>Nuovo</surname>
              </persName>
              <idno type="halauthorid">2917298-0</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-1073351"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marine</forename>
                <surname>Villard</surname>
              </persName>
              <idno type="idhal" notation="numeric">792144</idno>
              <idno type="halauthorid" notation="string">1396704-792144</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3905-8993</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-1073350"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">David</forename>
                <surname>Cluet</surname>
              </persName>
              <email type="md5">9c1630a77f44108f0db74117ed437ce1</email>
              <email type="domain">ens-lyon.fr</email>
              <idno type="idhal" notation="string">davidcluet</idno>
              <idno type="idhal" notation="numeric">1491153</idno>
              <idno type="halauthorid" notation="string">701157-1491153</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Magali</forename>
                <surname>Perret</surname>
              </persName>
              <idno type="halauthorid">186751-0</idno>
              <affiliation ref="#struct-222995"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rémi</forename>
                <surname>Pescamona</surname>
              </persName>
              <idno type="halauthorid">2917299-0</idno>
              <affiliation ref="#struct-222995"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Helena</forename>
                <surname>Paidassi</surname>
              </persName>
              <email type="md5">66838a527637c2da1fac13d694098430</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">helena-paidassi</idno>
              <idno type="idhal" notation="numeric">739515</idno>
              <idno type="halauthorid" notation="string">1446294-739515</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9915-4365</idno>
              <idno type="IDREF">https://www.idref.fr/135436559</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-1073349"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thierry</forename>
                <surname>Walzer</surname>
              </persName>
              <email type="md5">174d38cb2773573da6f40b713ffefeb9</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">thierry-walzer</idno>
              <idno type="idhal" notation="numeric">1038396</idno>
              <idno type="halauthorid" notation="string">220902-1038396</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0857-8179</idno>
              <idno type="IDREF">https://www.idref.fr/140356819</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-1073350"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Omran</forename>
                <surname>Allatif</surname>
              </persName>
              <email type="md5">5f29af27b239f53505c3889c20718128</email>
              <email type="domain">ens-lyon.fr</email>
              <idno type="idhal" notation="string">omran-allatif</idno>
              <idno type="idhal" notation="numeric">15068</idno>
              <idno type="halauthorid" notation="string">29041-15068</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2539-972X</idno>
              <idno type="IDREF">https://www.idref.fr/131297252</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-543554"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexandre</forename>
                <surname>Belot</surname>
              </persName>
              <email type="md5">a6ce3456bb5caf58ab3fc4cbd3676fef</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="idhal" notation="numeric">949521</idno>
              <idno type="halauthorid" notation="string">784683-949521</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4902-5332</idno>
              <idno type="IDREF">https://www.idref.fr/115823824</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-1073350"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sophie</forename>
                <surname>Trouillet-Assant</surname>
              </persName>
              <email type="md5">db83f52f6b3db3b70ee5ce43c52b62e0</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="idhal" notation="string">sophie-trouillet-assant</idno>
              <idno type="idhal" notation="numeric">777652</idno>
              <idno type="halauthorid" notation="string">1017157-777652</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6439-4705</idno>
              <idno type="IDREF">https://www.idref.fr/22729601X</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-1073355"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emiliano</forename>
                <surname>Ricci</surname>
              </persName>
              <email type="md5">25cd36b6725ff506b02e4f66a104dacd</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">emiliano-ricci</idno>
              <idno type="idhal" notation="numeric">13529</idno>
              <idno type="halauthorid" notation="string">1448984-13529</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9789-5837</idno>
              <idno type="IDREF">https://www.idref.fr/151546215</idno>
              <affiliation ref="#struct-489487"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marlène</forename>
                <surname>Dreux</surname>
              </persName>
              <email type="md5">102e656cb73e15f74eaec724ac898404</email>
              <email type="domain">ens-lyon.fr</email>
              <idno type="idhal" notation="string">marlene-dreux</idno>
              <idno type="idhal" notation="numeric">747673</idno>
              <idno type="halauthorid" notation="string">45362-747673</idno>
              <idno type="IDREF">https://www.idref.fr/157471667</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6607-4796</idno>
              <affiliation ref="#struct-222995"/>
              <affiliation ref="#struct-1073351"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Helena</forename>
                <surname>Paidassi</surname>
              </persName>
              <email type="md5">66838a527637c2da1fac13d694098430</email>
              <email type="domain">inserm.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-01-07 21:18:18</date>
              <date type="whenModified">2026-04-23 14:50:05</date>
              <date type="whenReleased">2025-01-08 16:11:02</date>
              <date type="whenProduced">2023-12</date>
              <date type="whenEndEmbargoed">2023-10-19</date>
              <ref type="file" target="https://hal.science/hal-04234855v1/document">
                <date notBefore="2023-10-19"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-04234855v1/file/s41467-023-36140-9.pdf" id="file-4249304-4238083">
                <date notBefore="2023-10-19"/>
              </ref>
              <ref type="externalLink" target="https://www.nature.com/articles/s41467-023-36140-9.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="95679">
                <persName>
                  <forename>Helena</forename>
                  <surname>Paidassi</surname>
                </persName>
                <email type="md5">66838a527637c2da1fac13d694098430</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04234855</idno>
            <idno type="halUri">https://hal.science/hal-04234855</idno>
            <idno type="halBibtex">venet:hal-04234855</idno>
            <idno type="halRefHtml">&lt;i&gt;Nature Communications&lt;/i&gt;, 2023, 14 (1), pp.694. &lt;a target="_blank" href="https://dx.doi.org/10.1038/s41467-023-36140-9"&gt;&amp;#x27E8;10.1038/s41467-023-36140-9&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Nature Communications, 2023, 14 (1), pp.694. &amp;#x27E8;10.1038/s41467-023-36140-9&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-4249304-4238083"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-ST-ETIENNE">Université Jean Monnet - Saint-Etienne</idno>
            <idno type="stamp" n="ENS-LYON">École Normale Supérieure de Lyon</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="CIRI" corresp="UNIV-LYON1">Centre International de Recherche en Infectiologie</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="CIRI-BIBS" corresp="CIRI">CIRI - BioInformatique et BioStatistiques</idno>
            <idno type="stamp" n="CIRI-O-THAUNAT-NOPAB" corresp="CIRI">CIRI - Cellules B normales et pathogéniques</idno>
            <idno type="stamp" n="CIRI-T-WALZER-LYACTS" corresp="CIRI">CIRI - Activation et transduction du signal dans les lymphocytes</idno>
            <idno type="stamp" n="CIRI-M-DREUX-VIV" corresp="CIRI">CIRI - Virus, Immunité innée et trafic Vésiculaire</idno>
            <idno type="stamp" n="CIRI-B-LINA-M-ROSA-CALATRAVA-VIRPATH" corresp="CIRI">CIRI - Virologie et Pathologies humaines</idno>
            <idno type="stamp" n="FRM">Fondation pour la Recherche Médicale</idno>
            <idno type="stamp" n="LBMC-UMR-5239">Laboratoire de Biologie et Modélisation de la Cellule</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Severe COVID-19 patients have impaired plasmacytoid dendritic cell-mediated control of SARS-CoV-2</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Manon</forename>
                    <surname>Venet</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1292207</idno>
                  <idno type="halauthorid" notation="string">2917295-1292207</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5065-8463</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-1073351"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Margarida Sa</forename>
                    <surname>Ribeiro</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1292208</idno>
                  <idno type="halauthorid" notation="string">2917296-1292208</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4768-9728</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-1073351"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elodie</forename>
                    <surname>Décembre</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1189897</idno>
                  <idno type="halauthorid" notation="string">867618-1189897</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6891-6320</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-1073351"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alicia</forename>
                    <surname>Bellomo</surname>
                  </persName>
                  <idno type="halauthorid">2053585-0</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-1073351"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Garima</forename>
                    <surname>Joshi</surname>
                  </persName>
                  <idno type="halauthorid">2917297-0</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-1073351"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Célia</forename>
                    <surname>Nuovo</surname>
                  </persName>
                  <idno type="halauthorid">2917298-0</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-1073351"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marine</forename>
                    <surname>Villard</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">792144</idno>
                  <idno type="halauthorid" notation="string">1396704-792144</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3905-8993</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-1073350"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">David</forename>
                    <surname>Cluet</surname>
                  </persName>
                  <email type="md5">9c1630a77f44108f0db74117ed437ce1</email>
                  <email type="domain">ens-lyon.fr</email>
                  <idno type="idhal" notation="string">davidcluet</idno>
                  <idno type="idhal" notation="numeric">1491153</idno>
                  <idno type="halauthorid" notation="string">701157-1491153</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Magali</forename>
                    <surname>Perret</surname>
                  </persName>
                  <idno type="halauthorid">186751-0</idno>
                  <affiliation ref="#struct-222995"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rémi</forename>
                    <surname>Pescamona</surname>
                  </persName>
                  <idno type="halauthorid">2917299-0</idno>
                  <affiliation ref="#struct-222995"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Helena</forename>
                    <surname>Paidassi</surname>
                  </persName>
                  <email type="md5">66838a527637c2da1fac13d694098430</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">helena-paidassi</idno>
                  <idno type="idhal" notation="numeric">739515</idno>
                  <idno type="halauthorid" notation="string">1446294-739515</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9915-4365</idno>
                  <idno type="IDREF">https://www.idref.fr/135436559</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-1073349"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thierry</forename>
                    <surname>Walzer</surname>
                  </persName>
                  <email type="md5">174d38cb2773573da6f40b713ffefeb9</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">thierry-walzer</idno>
                  <idno type="idhal" notation="numeric">1038396</idno>
                  <idno type="halauthorid" notation="string">220902-1038396</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0857-8179</idno>
                  <idno type="IDREF">https://www.idref.fr/140356819</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-1073350"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Omran</forename>
                    <surname>Allatif</surname>
                  </persName>
                  <email type="md5">5f29af27b239f53505c3889c20718128</email>
                  <email type="domain">ens-lyon.fr</email>
                  <idno type="idhal" notation="string">omran-allatif</idno>
                  <idno type="idhal" notation="numeric">15068</idno>
                  <idno type="halauthorid" notation="string">29041-15068</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2539-972X</idno>
                  <idno type="IDREF">https://www.idref.fr/131297252</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-543554"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexandre</forename>
                    <surname>Belot</surname>
                  </persName>
                  <email type="md5">a6ce3456bb5caf58ab3fc4cbd3676fef</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="idhal" notation="numeric">949521</idno>
                  <idno type="halauthorid" notation="string">784683-949521</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4902-5332</idno>
                  <idno type="IDREF">https://www.idref.fr/115823824</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-1073350"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sophie</forename>
                    <surname>Trouillet-Assant</surname>
                  </persName>
                  <email type="md5">db83f52f6b3db3b70ee5ce43c52b62e0</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="idhal" notation="string">sophie-trouillet-assant</idno>
                  <idno type="idhal" notation="numeric">777652</idno>
                  <idno type="halauthorid" notation="string">1017157-777652</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6439-4705</idno>
                  <idno type="IDREF">https://www.idref.fr/22729601X</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-1073355"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emiliano</forename>
                    <surname>Ricci</surname>
                  </persName>
                  <email type="md5">25cd36b6725ff506b02e4f66a104dacd</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">emiliano-ricci</idno>
                  <idno type="idhal" notation="numeric">13529</idno>
                  <idno type="halauthorid" notation="string">1448984-13529</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9789-5837</idno>
                  <idno type="IDREF">https://www.idref.fr/151546215</idno>
                  <affiliation ref="#struct-489487"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marlène</forename>
                    <surname>Dreux</surname>
                  </persName>
                  <email type="md5">102e656cb73e15f74eaec724ac898404</email>
                  <email type="domain">ens-lyon.fr</email>
                  <idno type="idhal" notation="string">marlene-dreux</idno>
                  <idno type="idhal" notation="numeric">747673</idno>
                  <idno type="halauthorid" notation="string">45362-747673</idno>
                  <idno type="IDREF">https://www.idref.fr/157471667</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6607-4796</idno>
                  <affiliation ref="#struct-222995"/>
                  <affiliation ref="#struct-1073351"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">67823</idno>
                <idno type="issn">2041-1723</idno>
                <idno type="eissn">2041-1723</idno>
                <title level="j">Nature Communications</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">14</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">694</biblScope>
                  <date type="datePub">2023-12</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/s41467-023-36140-9</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Abstract Type I and III interferons (IFN-I/λ) are important antiviral mediators against SARS-CoV-2 infection. Here, we demonstrate that plasmacytoid dendritic cells (pDC) are the predominant IFN-I/λ source following their sensing of SARS-CoV-2-infected cells. Mechanistically, this short-range sensing by pDCs requires sustained integrin-mediated cell adhesion with infected cells. In turn, pDCs restrict viral spread by an IFN-I/λ response directed toward SARS-CoV-2-infected cells. This specialized function enables pDCs to efficiently turn-off viral replication, likely via a local response at the contact site with infected cells. By exploring the pDC response in SARS-CoV-2 patients, we further demonstrate that pDC responsiveness inversely correlates with the severity of the disease. The pDC response is particularly impaired in severe COVID-19 patients. Overall, we propose that pDC activation is essential to control SARS-CoV-2-infection. Failure to develop this response could be important to understand severe cases of COVID-19.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="regrouplaboratory" xml:id="struct-222995" status="VALID">
          <idno type="IdRef">17825696X</idno>
          <idno type="ISNI">0000000404506033</idno>
          <idno type="RNSR">201320572J</idno>
          <idno type="ROR">https://ror.org/059sz6q14</idno>
          <idno type="Wikidata">Q30261449</idno>
          <orgName>Centre International de Recherche en Infectiologie</orgName>
          <orgName type="acronym">CIRI</orgName>
          <date type="start">2013-01-01</date>
          <desc>
            <address>
              <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ciri.inserm.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-6818" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-300284" type="direct"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U1111" active="#struct-303623" type="direct"/>
            <relation name="UMR5308" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1073351" status="VALID">
          <orgName>Virus, immunité innée et trafic vésiculaire - Vesicular trafficking, innate response and viruses [CIRI]</orgName>
          <orgName type="acronym">CIRI-VIV</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://ciri.ens-lyon.fr/teams/VIV</ref>
          </desc>
          <listRelation>
            <relation active="#struct-222995" type="direct"/>
            <relation active="#struct-6818" type="indirect"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="indirect"/>
            <relation active="#struct-300284" type="indirect"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U1111" active="#struct-303623" type="indirect"/>
            <relation name="UMR5308" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1073350" status="VALID">
          <orgName>Activation et transduction du signal dans les lymphocytes - Lymphocyte activation and signaling [CIRI]</orgName>
          <orgName type="acronym">CIRI-LYACTS</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://ciri.ens-lyon.fr/teams/lyacts</ref>
          </desc>
          <listRelation>
            <relation active="#struct-222995" type="direct"/>
            <relation active="#struct-6818" type="indirect"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="indirect"/>
            <relation active="#struct-300284" type="indirect"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U1111" active="#struct-303623" type="indirect"/>
            <relation name="UMR5308" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1073349" status="VALID">
          <orgName>Cellules B normales et pathogéniques - Normal and pathogenic B cell responses [CIRI]</orgName>
          <orgName type="acronym">CIRI-NOPAB</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://ciri.ens-lyon.fr/teams/nopab</ref>
          </desc>
          <listRelation>
            <relation active="#struct-222995" type="direct"/>
            <relation active="#struct-6818" type="indirect"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="indirect"/>
            <relation active="#struct-300284" type="indirect"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U1111" active="#struct-303623" type="indirect"/>
            <relation name="UMR5308" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-543554" status="VALID">
          <orgName>BioInformatique et BioStatistiques [CIRI]</orgName>
          <orgName type="acronym">CIRI-BIBS</orgName>
          <date type="start">2013-01-01</date>
          <desc>
            <address>
              <addrLine>CIRI46 Allée d’Italie69364 Lyon Cedex 07France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ciri.inserm.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-222995" type="direct"/>
            <relation active="#struct-6818" type="indirect"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="indirect"/>
            <relation active="#struct-300284" type="indirect"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U1111" active="#struct-303623" type="indirect"/>
            <relation name="UMR5308" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1073355" status="VALID">
          <orgName>Virology and human respiratory Pathologies - Virology and human respiratory Pathologies [CIRI]</orgName>
          <orgName type="acronym">CIRI-VirPath</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://ciri.ens-lyon.fr/teams/VirPath</ref>
          </desc>
          <listRelation>
            <relation active="#struct-222995" type="direct"/>
            <relation active="#struct-6818" type="indirect"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="indirect"/>
            <relation active="#struct-300284" type="indirect"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U1111" active="#struct-303623" type="indirect"/>
            <relation name="UMR5308" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-489487" status="VALID">
          <idno type="IdRef">166612049</idno>
          <idno type="ISNI">0000000405980706</idno>
          <idno type="RNSR">200711906R</idno>
          <idno type="ROR">https://ror.org/01bj4fd12</idno>
          <idno type="Wikidata">Q30261611</idno>
          <orgName>Laboratoire de biologie et modélisation de la cellule</orgName>
          <orgName type="acronym">LBMC UMR 5239</orgName>
          <date type="start">2007-01-01</date>
          <desc>
            <address>
              <addrLine>Ecole Normale Supérieure46 Allée d'Italie69364 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ens-lyon.fr/LBMC/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-6818" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="direct"/>
            <relation name="U1210" active="#struct-303623" type="direct"/>
            <relation name="UMR5239" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-6818" status="VALID">
          <idno type="IdRef">149154992</idno>
          <idno type="ISNI">0000000123319856</idno>
          <idno type="ROR">https://ror.org/04zmssz18</idno>
          <idno type="Wikidata">Q10159</idno>
          <orgName>École normale supérieure de Lyon</orgName>
          <orgName type="acronym">ENS de Lyon</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ens-lyon.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300284" status="VALID">
          <idno type="IdRef">028209966</idno>
          <idno type="ISNI">0000 0001 2158 1682</idno>
          <idno type="ROR">https://ror.org/04yznqr36</idno>
          <idno type="Wikidata">Q623154</idno>
          <orgName>Université Jean Monnet - Saint-Étienne</orgName>
          <orgName type="acronym">UJM</orgName>
          <date type="start">1969-03-27</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10, Rue Tréfilerie – CS 8230142023 Saint-Étienne Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1327915" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1327915" status="VALID">
          <idno type="IdRef">285395831</idno>
          <orgName>Université Jean Monnet (EPSCPE)</orgName>
          <orgName type="acronym">UJM EPE</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10 rue Tréfilerie42100 Saint-Etienne</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/fr/index.html</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>