<i>N</i>‐Fluoro Ammonium Salts of <i>Cinchona</i> Alkaloids in Enantioselective Electrophilic Fluorination - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Chemical Record Année : 2023

N‐Fluoro Ammonium Salts of Cinchona Alkaloids in Enantioselective Electrophilic Fluorination

Résumé

From 2000, our two research groups independently and simultaneously designed and developed a novel family of electrophilic fluorinating reagents based on the use of Cinchona alkaloids. The chiral N-fluoro ammonium salts demonstrated the highest efficiency compared to prior art in enantioselective electrophilic fluorination for a wide range of substrates. In this account, we tell our respective stories, how the same idea germinated in our laboratories, the characterization of the chiral reagents, the use in stoichiometric quantity then the development of a catalytic version, the application to the synthesis of chiral fluorinated molecules of pharmaceutical interest, and finally the exploitation of our reagents by other teams and for other applications.
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Dates et versions

hal-04234794 , version 1 (10-10-2023)

Identifiants

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Norio N Shibata, Dominique Cahard. N‐Fluoro Ammonium Salts of Cinchona Alkaloids in Enantioselective Electrophilic Fluorination. Chemical Record, 2023, Synthesis and Applications of Organofluorine Compounds, 23 (9), pp.e202300096. ⟨10.1002/tcr.202300096⟩. ⟨hal-04234794⟩
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