Toward a bona fide animal model of PLA2R1-associated membranous nephropathy: one step forward - Archive ouverte HAL
Article Dans Une Revue Kidney International Année : 2023

Toward a bona fide animal model of PLA2R1-associated membranous nephropathy: one step forward

Résumé

The major form of membranous nephropathy is characterized by autoantibodies to phospholipase A2 receptor 1 (PLA2R1). The study by Tomas et al. describes the first animal model where human PLA2R1 is ectopically expressed in mouse podocytes. Intriguingly, the transgenic mice spontaneously develop anti-human PLA2R1 antibodies and membranous nephropathy-like features, including immune deposits and nephrotic syndrome. The model raises questions about the spontaneous production of anti-human PLA2R1 antibodies and the additional steps to establish a bona fide animal model of membranous nephropathy.
Fichier principal
Vignette du fichier
Bihl and Lambeau KI commentary 2023.pdf (511.11 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04234786 , version 1 (10-10-2023)

Identifiants

Citer

Franck Bihl, Gérard Lambeau. Toward a bona fide animal model of PLA2R1-associated membranous nephropathy: one step forward. Kidney International, 2023, 103 (2), pp.251 - 253. ⟨10.1016/j.kint.2022.10.020⟩. ⟨hal-04234786⟩
30 Consultations
56 Téléchargements

Altmetric

Partager

More