Monofluoromethylation of Cyclic Sulfamidates and Sulfates with a-Fluorocarbanions of Fluorobis(phenylsulfonyl)methane and Ethyl 2-Fluoroacetoacetate
Résumé
A regioselective fluoromethylation by ring-opening of cyclic sulfamidates and sulfates with a-fluorocarbanions and subsequent reductive desulfonylation is developed. Fluorobis(phenylsulfonyl)methane (FBSM) was explored as fluoromethide equivalent and the reaction was extended to the afluorocarbanion of ethyl 2-fluoroacetoacetate. This approach allows access to g-and d-fluoroamines as well as g-and d-fluoroalcohols in high yields.
Domaines
Chimie| Origine | Fichiers produits par l'(les) auteur(s) |
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