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Article Dans Une Revue (Article De Synthèse) mBio Année : 2023

Replication mechanisms of circular ssDNA plant viruses and their potential implication in viral gene expression regulation

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The replication of members of the two circular single-stranded DNA (ssDNA) virus families Geminiviridae and Nanoviridae , the only ssDNA viruses infecting plants, is believed to be processed by rolling-circle replication (RCR) and recombination-dependent replication (RDR) mechanisms. RCR is a ubiquitous replication mode for circular ssDNA viruses and involves a virus-encoded Replication-associated protein (Rep) which fulfills multiple functions in the replication mechanism. Two key genomic elements have been identified for RCR in Geminiviridae and Nanoviridae : (i) short iterative sequences called iterons which determine the specific recognition of the viral DNA by the Rep and (ii) a sequence enabling the formation of a stem-loop structure which contains a conserved motif and constitutes the origin of replication. In addition, studies in Geminiviridae provided evidence for a second replication mode, RDR, which has also been documented in some double-stranded DNA viruses. Here, we provide a synthesis of the current understanding of the two presumed replication modes of Geminiviridae and Nanoviridae , and we identify knowledge gaps and discuss the possibility that these replication mechanisms could regulate viral gene expression through modulation of gene copy number.
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hal-04232716 , version 1 (09-10-2023)

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Mélia Bonnamy, Stéphane Blanc, Yannis Michalakis. Replication mechanisms of circular ssDNA plant viruses and their potential implication in viral gene expression regulation. mBio, 2023, 14 (5), pp.e01692-23. ⟨10.1128/mbio.01692-23⟩. ⟨hal-04232716⟩
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