Research on Emerging Medical radionuclides from the X-sections (REMIX): The Accelerator-based Production of $^{47}$Sc, $^{149}$Tb, $^{152}$Tb, $^{155}$Tb and $^{161}$Tb
Résumé
The REMIX project is focused on the cyclotron-based production of $^{47}$Sc, $^{149}$Tb, $^{152}$Tb, $^{155}$Tb and $^{161}$Tb radionuclides, whose decay characteristics make them suitable for medical applications. This work will outline the main results achieved withing the REMIX collaboration, that is organized in the following Work Packages (WP): WP1. Target manufacturing ($^{49}$Ti, $^{50}$Ti and $^{155}$Gd$_{2}$O$_{3}$) and characterization; WP2. Nuclear cross section (XS) measurements with $^{49}$Ti and $^{50}$Ti targets for $^{47}$Sc production; WP3. Nuclear XS measurements with $^{nat}$Dy, $^{159}$Tb and $^{nat}$Eu targets for $^{xx}$Tb production; WP4. Nuclear XS modeling for $^{47}$Sc and $^{155}$Tb production; WP5. Dosimetric calculations for $^{47}$Sc- and $^{xx}$Tb-labelled radiopharmaceuticals; WP6. $^{155}$Tb Thick Target Yield (TTY) measurements; WP7. Apparatus design and realization for irradiation tests with the LARAMED beamline. Since the LARAMED bunkers and ancillary laboratories are currently under completion at the INFN-LNL, the nuclear XS experiments are carried out in collaboration with the GIP ARRONAX facility (Saint-Herblain, France) and the Thick Target Yield (TTY) measurements are performed at the Sacro Cuore Don Calabria hospital (SCDCh, Negrar, Verona, Italy).