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Article Dans Une Revue Proteins - Structure, Function and Bioinformatics Année : 2023

Protein target highlights in CASP15 : Analysis of models by structure providers

1 Biozentrum [Basel, Suisse]
2 SIB - Swiss Institute of Bioinformatics [Genève]
3 Genome Center [UC Davis]
4 EPFL - Ecole Polytechnique Fédérale de Lausanne
5 UNIMI - Università degli Studi di Milano = University of Milan
6 NYU Grossman School of Medicine - New York University School of Medicine
7 IBS - UMR 5075 - Institut de biologie structurale
8 University of Birmingham [Birmingham]
9 MIT - Massachusetts Institute of Technology
10 Edin. - University of Edinburgh
11 Department of Chemistry [Ann Arbor]
12 Universität Bielefeld = Bielefeld University
13 University of Otago [Dunedin, Nouvelle-Zélande]
14 The Wellcome Trust Centre for Human Genetics [Oxford]
15 Monash University [Clayton]
16 Max Planck Institute for Developmental Biology
17 LISCB - Leicester Institute of Structural and Chemical Biology [Leicester]
18 University of Oxford
19 Department of Biology and Biocenter Oulu
20 UiB - University of Bergen
21 UCLA - University of California [Los Angeles]
22 Lanzhou University
23 Rice University [Houston]
24 Feinberg School of Medicine
25 Georg-August-University = Georg-August-Universität Göttingen
26 Institute of Agricultural Biology and Biotechnology
27 University of Nebraska–Lincoln
28 UC Davis - University of California [Davis]
29 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
30 LIV - Leibniz-Institut für Virologie [Hamburg]
31 IBBR - Institute for Bioscience and Biotechnology Research [Rockville, MD, États-Unis]
Andriy Kryshtafovych
Gira Bhabha
Cécile Breyton
Simon Caulton
James Chen
Séraphine Degroux
Damian Ekiert
Benedikte Erlandsen
Peter Freddolino
Rhys Grinter
Manickam Gurusaran
Jeremy Keown
Ashleigh Kropp
Andrew Lovering
Shiheng Liu
Shuze Lu
  • Fonction : Auteur
Sigurbjörn Markússon
Mitchell Miller
George Minasov
George Phillips
Owen R. Davies
Monica Rosas-Lemus
Karla Satchell
Mark Wilson
Xian Xia
Han Xiao
Wenhua Zhang
Krzysztof Fidelis
Torsten Schwede

Résumé

We present an in‐depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three‐dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.
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Licence : CC BY - Paternité

Dates et versions

hal-04231019 , version 1 (22-11-2023)

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Paternité

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Leila T. Alexander, Janani Durairaj, Andriy Kryshtafovych, Luciano A. Abriata, Yusupha Bayo, et al.. Protein target highlights in CASP15 : Analysis of models by structure providers. Proteins - Structure, Function and Bioinformatics, 2023, 2023, prot.26545. ⟨10.1002/prot.26545⟩. ⟨hal-04231019⟩
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