Biological relevance and targeting of i-motif DNA
Résumé
i-Motifs of DNA (hereafter, i-DNA), known in vitro for nearly three decades, are unusual, four-stranded structures, in which cytosines are intercalated via a stack of hemi-protonated C–C base pairs (CH+:C) (Fig. 1A, B). Some of these structures have been well characterized in vitro and, because i-DNA may mirror other four-stranded G-rich structures (G-quadruplexes) present in gene promoters or at telomeres, their biological relevance is being investigated.
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Soumis le : lundi 2 octobre 2023-10:42:47
Dernière modification le : mercredi 18 décembre 2024-10:12:35
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- HAL Id : hal-04224591 , version 1
Citer
Hugues Bonnet, Dennis Gomez, Jean-François Riou, Anton Granhzam, Eric Defrancq, et al.. Biological relevance and targeting of i-motif DNA. journées scientifiques du GDR ChemBio, Jun 2023, STRASBOURG, France. ⟨hal-04224591⟩
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