Biological relevance and targeting of i-motif DNA - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2023

Biological relevance and targeting of i-motif DNA

Résumé

i-Motifs of DNA (hereafter, i-DNA), known in vitro for nearly three decades, are unusual, four-stranded structures, in which cytosines are intercalated via a stack of hemi-protonated C–C base pairs (CH+:C) (Fig. 1A, B). Some of these structures have been well characterized in vitro and, because i-DNA may mirror other four-stranded G-rich structures (G-quadruplexes) present in gene promoters or at telomeres, their biological relevance is being investigated.
c524d468-4ecb-4ecd-a26c-334198dfb559-author.pdf (242.64 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04224591 , version 1 (02-10-2023)

Identifiants

  • HAL Id : hal-04224591 , version 1

Citer

Hugues Bonnet, Dennis Gomez, Jean-François Riou, Anton Granhzam, Eric Defrancq, et al.. Biological relevance and targeting of i-motif DNA. journées scientifiques du GDR ChemBio, Jun 2023, STRASBOURG, France. ⟨hal-04224591⟩
32 Consultations
6 Téléchargements

Partager

Gmail Mastodon Facebook X LinkedIn More