An unbiased screening for transcription factors and chromatin remodelers that reset pluripotent stem cells to naïve-like pluripotency - Archive ouverte HAL
Communication Dans Un Congrès Année : 2021

An unbiased screening for transcription factors and chromatin remodelers that reset pluripotent stem cells to naïve-like pluripotency

Résumé

Pluripotent Stem Cells (PSCs) include embryo-derived and induced pluripotent stem cells (ESCs and iPSCs, respectively). Mouse PSCs can be stabilized in vitro in two pluripotent states : the naive state and the primed state. Naïve and primed states differ by the signalling pathways, transcription factors and epigenetic regulators that hold the cells in one of either state. Only the naïve mESCs have the ability to colonize the epiblast of the blastocyst and generate chimeras; PSCs in the primed state cannot. In rabbits and other non-rodent species, cells derived from early epiblast or generated by somatic cell reprogramming can only be maintained in the primed state of pluripotency. This study aims to identify genes capable of reprogramming conventional primed rabbit iPSCs (rbiPSCs) to the naïve state of pluripotency.
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Dates et versions

hal-04219140 , version 1 (26-09-2023)

Identifiants

  • HAL Id : hal-04219140 , version 1

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Florence Perold, Anaïs Moulin, Thierry Joly, Nathalie Doerflinger, Nathalie Beaujean, et al.. An unbiased screening for transcription factors and chromatin remodelers that reset pluripotent stem cells to naïve-like pluripotency. FSSCR ANNUAL MEETING 2021 PROGRAM, French Society for Stel Cell Research, Nov 2021, Montpellier, France. ⟨hal-04219140⟩
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