We consider a Laplace type problem with a generalized impedance boundary condition of the form ∂_νu = −∂_x(g∂_xu) on a flat part Γ of the boundary. Here ν is the outward unit normal vector to ∂Ω, g is the impedance function and x is the coordinate along Γ. Such problems appear for example in the modelling of small perturbations of the boundary. In the literature, the cases g=1 or g=−1 have been investigated. In this work, we address situations where Γ contains the origin and g(x)=1_{x>0}(x)x^\alpha or g(x)=−sign(x)|x|^\alpha with \alpha≥ 0. In other words, we study cases where g vanishes at the origin and changes its sign. The main message is that the well-posedness in the Fredholm sense of the corresponding problems depends on the value of \alpha. For \alpha∈ [0,1), we show that the associated operators are Fredholm of index zero while it is not the case when \alpha=1. The proof of the first results is based on the reformulation as 1D problems combined with the derivation of compact embedding results for the functional spaces involved in the analysis. The proof of the second results relies on the computation of singularities and the construction of Weyl's sequences. We also discuss the equivalence between the strong and weak formulations, which is not straightforward. Finally, we provide simple numerical experiments which seem to corroborate the theorems.