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Article Dans Une Revue ACS Organic & Inorganic Au Année : 2023

Asymmetric Syntheses of Enantioenriched 2,5-Disubstituted Pyrrolidines

Résumé

C2-Symmetrical scaffolds are privileged ligands in metal catalysis and are also widely used in organocatalysis. Among these, 2,5-disubstituted pyrrolidines hold a paramount importance especially since they also find application in medicinal chemistry. This review highlights the stereoselective syntheses of these C2-symmetrical nitrogen heterocycles. It includes the synthetic strategies based on the use of the chiral pool as well as the more recent sequences designed following major achievements in asymmetric catalysis.
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Dates et versions

hal-04210008 , version 1 (18-09-2023)

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Yanis Lazib, Junio Guimaraes Naves, Agnès Labande, Philippe Dauban, Tanguy Saget. Asymmetric Syntheses of Enantioenriched 2,5-Disubstituted Pyrrolidines. ACS Organic & Inorganic Au, 2023, 3 (3), pp.120-129. ⟨10.1021/acsorginorgau.2c00061⟩. ⟨hal-04210008⟩
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