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Article Dans Une Revue Current Opinion in Neurobiology Année : 2018

Towards resolving the presynaptic NMDA receptor debate

Résumé

In the classical view, postsynaptic NMDA receptors (NMDARs) trigger Hebbian plasticity via Ca2+ influx. However, unconventional presynaptic NMDARs (preNMDARs) which regulate both long-term and short-term plasticity at several synapse types have also been found. A lack of sufficiently specific experimental manipulations and a poor understanding of how preNMDARs signal have contributed to long-standing controversy surrounding these receptors. Although several prior studies linked preNMDARs to neocortical timing-dependent long-term depression (tLTD), a recent study argues that the NMDARs are actually postsynaptic and signal metabotropically, that is, without Ca2+. Other recent work indicates that, whereas ionotropic preNMDARs signaling controls evoked release, spontaneous release is regulated by metabotropic NMDAR signaling. We argue that elucidating unconventional NMDAR signaling modes-both presynaptically and metabotropically-is key to resolving the preNMDAR debate.

Dates et versions

hal-04209764 , version 1 (18-09-2023)

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Guy Bouvier, Rylan Larsen, P. Jesper Sjöström, Antonio Rodríguez-Moreno, Ole Paulsen. Towards resolving the presynaptic NMDA receptor debate. Current Opinion in Neurobiology, 2018, 51, pp.1-7. ⟨10.1016/j.conb.2017.12.020⟩. ⟨hal-04209764⟩
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