Under environmental action, reinforced concrete (RC) structures might suffer from reinforcement corrosion caused by the surrounding environment, dramatically reducing structural reliability and threatening social development. However, most of the existing reliability assessment methods for RC structures only focused on the structural performance at the design stage given the original unchanged environment, ignoring the effects of realistic exposure conditions and inspection results on reliability evaluation. Thus, this paper develops a general reliability assessment framework based on a Mixed Bayesian network (MBN), incorporating three modules, i.e., durability assessment, load-bearing capacity analysis, and time-dependent reliability analysis. In MBN, separate sub-BNs are built based on different modules and connected by pinch point variables where probabilistic information is transmitted via soft evidence. Besides, this framework considers time-dependent environmental parameters and two-dimensional chloride transport and their effects on reliability. Meanwhile, adjustment coefficients are applied to improve the results of the analytical mechanical model with respect to different limit states through the finite element model (FEM). The proposed MBN framework is illustrated for a corroded RC beam under a marine atmospheric environment to investigate the effects of environmental modeling, chloride transport patterns, and concrete crack inspection on reliability assessment. The results indicate that under the assumed conditions in the case study, early inspection of large cracks may significantly overestimate the failure probability by about 500%. Besides, failure probability might be underestimated by about 95%, ignoring the time-variant environment and two-dimensional chloride transport.