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Article Dans Une Revue The American Journal of Clinical Nutrition Année : 2011

Polymorphisms in the CD36/FAT gene are associated with plasma vitamin E concentrations in humans

Sophie Lecompte
  • Fonction : Auteur
Fabien Szabo de Edelenyi
  • Fonction : Auteur
Louisa Goumidi
  • Fonction : Auteur
Giuseppe Maiani
  • Fonction : Auteur
George Moschonis
  • Fonction : Auteur
Kurt Widhalm
  • Fonction : Auteur
Dénes Molnár
  • Fonction : Auteur
Anthony Kafatos
  • Fonction : Auteur
Andre Spinneker
  • Fonction : Auteur
Christina Breidenassel
  • Fonction : Auteur
Jean Dallongeville
  • Fonction : Auteur
Aline Meirhaeghe
  • Fonction : Auteur

Résumé

Background: Blood vitamin E concentrations are modulated by dietary, metabolic, and genetic factors. CD36 (cluster of differentiation 36), a class B scavenger receptor, might be involved in tissue vitamin E uptake and thus would influence blood vitamin E concentrations. Objective: The goal of the study was to assess the association between CD36 single nucleotide polymorphisms (SNPs) and plasma a-tocopherol concentrations in humans. Design: A subsample from the adult SU.VI.MAX (SUpplementation en VItamines et Mine ´raux AntioXydants) cohort (n = 621) and the adolescent cross-sectional HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study (n = 993) were genotyped for CD36 SNPs (4 and 10 SNPs, respectively). Fasting plasma a-tocopherol concentrations were assayed by using HPLC. Associations were determined by haplotype analyses and by general linear regression models. Results: In the SU.VI.MAX subsample, haplotype analyses showed that some haplotypes of SNPs rs1984112, rs1527479, rs7755, and rs1527483 tended to be associated with plasma a-tocopherol concentrations (P = 0.08 and P = 0.09 for haplotypes 1222 and 1122, respectively). We then investigated the whole known common genetic variability (10 SNPs) of CD36 in the HELENA Study. Three SNPs were associated with lower plasma a-tocopherol concentrations (rs1984112: 23.2%, P = 0.053; rs1761667: 22.9%, P = 0.046; rs1527479: 23.7%, P = 0.0061). After correction for multiple testing, the association between rs1527479 and a-tocopherol concentrations remained significant. This association was modulated by concentrations of fasting serum triglycerides (P for interaction = 0.006) and long-chain polyunsaturated fatty acids (P for interaction = 0.005). Conclusion: Our results suggest that CD36 can modulate blood a-tocopherol concentrations and may therefore be involved in the intestinal absorption or tissue uptake of vitamin E.
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hal-04208408 , version 1 (15-09-2023)

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Sophie Lecompte, Fabien Szabo de Edelenyi, Louisa Goumidi, Giuseppe Maiani, George Moschonis, et al.. Polymorphisms in the CD36/FAT gene are associated with plasma vitamin E concentrations in humans. The American Journal of Clinical Nutrition, 2011, 93 (3), pp.644 - 651. ⟨10.3945/ajcn.110.004176⟩. ⟨hal-04208408⟩
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