Memory enhancement by ferulic acid ester across species - Archive ouverte HAL
Article Dans Une Revue Science Advances Année : 2018

Memory enhancement by ferulic acid ester across species

Birgit Michels
Hanna Zwaka
Ruth Bartels
Oleh Lushchak
Katrin Franke
  • Fonction : Auteur
Thomas Endres
Markus Fendt
Inseon Song
May Bakr
Tuvshinjargal Budragchaa
  • Fonction : Auteur
Bernhard Westermann
Dushyant Mishra
  • Fonction : Auteur
Stefanie Schreyer
  • Fonction : Auteur
Annika Lingnau
  • Fonction : Auteur
Caroline Vahl
Marike Hilker
  • Fonction : Auteur
Randolf Menzel
  • Fonction : Auteur
Thilo Kähne
  • Fonction : Auteur
Volkmar Leßmann
Alexander Dityatev
Ludger Wessjohann
Bertram Gerber

Résumé

Inspired from plant medicine, a drug that partially compensates for memory decline in aged flies and mice is identified. Cognitive impairments can be devastating for quality of life, and thus, preventing or counteracting them is of great value. To this end, the present study exploits the potential of the plant Rhodiola rosea and identifies the constituent ferulic acid eicosyl ester [icosyl-(2E)-3-(4-hydroxy-3-methoxyphenyl)-prop-2-enoate (FAE-20)] as a memory enhancer. We show that food supplementation with dried root material from R. rosea dose-dependently improves odor-taste reward associative memory scores in larval Drosophila and prevents the age-related decline of this appetitive memory in adult flies. Task-relevant sensorimotor faculties remain unaltered. From a parallel approach, a list of candidate compounds has been derived, including R. rosea-derived FAE-20. Here, we show that both R. rosea-derived FAE-20 and synthetic FAE-20 are effective as memory enhancers in larval Drosophila. Synthetic FAE-20 also partially compensates for age-related memory decline in adult flies, as well as genetically induced early-onset loss of memory function in young flies. Furthermore, it increases excitability in mouse hippocampal CA1 neurons, leads to more stable context-shock aversive associative memory in young adult (3-month-old) mice, and increases memory scores in old (>2-year-old) mice. Given these effects, and given the utility of R. rosea-the plant from which we discovered FAE-20-as a memory enhancer, these results may hold potential for clinical applications.

Dates et versions

hal-04204818 , version 1 (12-09-2023)

Identifiants

Citer

Birgit Michels, Hanna Zwaka, Ruth Bartels, Oleh Lushchak, Katrin Franke, et al.. Memory enhancement by ferulic acid ester across species. Science Advances , 2018, 4 (10), pp.eaat6994. ⟨10.1126/sciadv.aat6994⟩. ⟨hal-04204818⟩
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