Three mesocyclones (MCs) over the Russian (Eastern) Arctic are investigated using multispectral satellite remote sensing data, surface analysis maps, and reanalysis data. Advanced retrieval algorithms are used for estimating the geophysical parameter from satellite passive microwave measurements. These methods allow reconstructing in full the geophysical parameter fields characterizing polar lows. Synoptic analysis along with cloud image, atmospheric water vapor content, cloud liquid water content, and sea surface wind speed field analysis show that, while the Arctic sea ice retreats, new areas of open water appear where MCs can arise. A detailed study of several polar low cases reveals the typical conditions of their formation and development. Further studies are in demand due to the danger of MC extreme events for navigation, transport, and fishery operations in these unexplored regions.