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Article Dans Une Revue Advances in Radiation Oncology Année : 2023

Deficient Radiation Transcription Response in COVID-19 Patients

Résumé

Purpose: The ongoing SARS-CoV-2 pandemic has resulted in over 6.3 million deaths and 560 million COVID-19 cases worldwide. Clinical management of hospitalized patients is complex due to the heterogeneous course of COVID-19. Low-dose radiation therapy is known to dampen localized chronic inflammation and has been suggested to be used to reduce lung inflammation in patients with COVID-19. However, it is unknown whether SARS-CoV-2 alters the radiation response and associated radiation exposure related risk. Methods and Materials: We generated gene expression profiles from circulating leukocytes of hospitalized patients with COVID-19 and healthy donors. Results: The p53 signaling pathway was found to be dysregulated, with mRNA levels of p53, ATM, and CHK2 being lower in patients with COVID-19. Several key p53 target genes involved in cell cycle arrest, apoptosis, and p53 feedback inhibition were upregulated in patients with COVID-19 while other p53 target genes were downregulated. This dysregulation has functional consequences as the transcription of p53-dependant genes (CCNG1, GADD45A, DDB2, SESN1, FDXR, APOBEC) was reduced 24 hours after x-ray exposure ex vivo to both low (100 mGy) or high (2 Gy) doses. Conclusions: SARS-CoV-2 infection affects a DNA damage response that may modify radiation-induced health risks in exposed patients with COVID-19.
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Dates et versions

hal-04199354 , version 1 (12-09-2023)

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Stanislav Polozov, Lourdes Cruz-Garcia, Grainne O'Brien, Veronika Goriacha, Farah Nasser, et al.. Deficient Radiation Transcription Response in COVID-19 Patients. Advances in Radiation Oncology, 2023, 8 (4), pp.101215. ⟨10.1016/j.adro.2023.101215⟩. ⟨hal-04199354⟩
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