Article Dans Une Revue JNCI: Journal of the National Cancer Institute Année : 2003

Macrophages From Cancer Patients: Analysis of TRAIL, TRAIL Receptors, and Colon Tumor Cell Apoptosis

Claude Lambert
  • Fonction : Auteur
Odile Sabido
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  • PersonId : 1152705
Michèle Cottier
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  • PersonId : 867321
  • IdRef : 112496946
Pierre Fournel
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Michel Dy
  • Fonction : Auteur
Christian Genin
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  • PersonId : 1281355

Résumé

Tumor-infiltrating macrophages secrete cytokines, including Fas ligand, tumor necrosis factor-alpha (TNF-alpha), and TNF-related apoptosis-inducing ligand (TRAIL). TRAIL induces apoptosis in tumor cells but not in normal cells; however, regulation of TRAIL and its receptors in cancer patients is relatively uncharacterized. We investigated whether macrophages from cancer patients produce TRAIL and whether apoptosis in cultured colon adenocarcinoma cells involves TRAIL and its receptors.

Dates et versions

hal-04198816 , version 1 (07-09-2023)

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Citer

Jean-Philippe Herbeuval, Claude Lambert, Odile Sabido, Michèle Cottier, Pierre Fournel, et al.. Macrophages From Cancer Patients: Analysis of TRAIL, TRAIL Receptors, and Colon Tumor Cell Apoptosis. JNCI: Journal of the National Cancer Institute, 2003, 95 (8), pp.611-621. ⟨10.1093/jnci/95.8.611⟩. ⟨hal-04198816⟩
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