Successful Thrombectomy Improves Functional Outcome in Tandem Occlusions with a Large Ischemic Core
Benjamin Gory
(1)
,
Stephanos Nikolaos Finitsis
(2)
,
Jean Philippe Desilles
(3)
,
Arturo Consoli
(4, 5)
,
Mikael Mazighi
(3)
,
Gaultier Marnat
(6)
,
Igor Sibon
(6)
,
Raoul Pop
(7)
,
Nicolas Raposo
(8, 9)
,
Valérie Wolff
(10)
,
Christophe H. Cognard
(11)
,
Śebastien Richard
,
Solène Moulin
(12)
,
Sébastien Soize
(12)
,
Bertrand Lapergue
(4, 5)
,
Adrien Wang
(5)
,
Oguzhan Coskun
(13)
,
Federico Maria
(14)
,
Silvia Pizzuto
(13)
,
Alessandro Sgreccia
(13)
,
Charline Benoit
(15)
,
Lucas Gorza
(5)
,
David Weisenburger-Lile
(5)
,
Waliyde Jabeur
(16)
,
Tchikviladze Maia
,
Serge Evrard
(17)
,
Georges L. Rodesch
,
Raphaël Blanc
(18)
,
Michaël Alexandre Obadia
,
Michel P. Piotin
(19)
,
Pierre Seners
(19)
,
Stanislas J. Smajda
,
Simon Escalard
(19)
,
Benjamin Maier
,
Candice Sabben
,
Hocine Redjem
,
Grace Adwan
,
François Delvoye
,
Amira Al Raaisi
,
William Boisseau
,
Omer Faruk Eker
,
Tae-Hee Cho
,
Laurent Derex
,
Julia Fontaine
,
Laura Mechtouff
,
Norbert Nighoghossian
,
Elodie Ong
,
Lucie Rascle
,
Roberto Riva
,
Françis Turjman
,
Morgane Laubacher
,
Mehdi Beyragued
,
Yves Berthezene
,
Marc R. Hermier
,
Ameli Roxanna
,
Alexandre Bani-Sadr
,
Andrea Filip
,
Matteo Cappucci
,
Romain Bourcier
,
Benjamin Daumas Duport
,
Pierre Louis Alexandre
,
Cédric Lenoble
,
Solène De Gaalon
,
Benoît Guillon
,
Cécile Preterre
,
Guillaume Tessier
,
Arthur Lionnet
,
Lisa Humbertjean-Selton
,
René Anxionnat
,
Anne Laure Derelle
,
Liang Liao
,
Emmanuelle Schmitt
,
Sophie Planel
,
Gioia Mione
,
Jean Christophe Lacour
,
Marian Douarinou
,
Emilien Micard
,
Bailiang Chen
,
Gérard B. Audibert
,
Agnès Masson
,
Lionel Alb
,
Marine Beaumont
,
Adriana Tabarna
,
Marcela Voicu
,
Grégoire Barthel
,
Iona Podar
,
Madalina Brezeanu
,
Marie Reitter
,
François Zhu
,
Jean Sébastien Liegey
,
Pierre Briau
,
Lisa Papillon
,
Xavier Barreau
,
Jean Papaxanthos
,
Jerome Berge
,
Sabrina Debruxelles
,
Stéphane Olindo
,
Mathilde Poli
,
Pauline Renou
,
Sharmila Sagnier
,
Thomas Tourdias
,
Thomas Courret
,
Ludovic Lucas
,
Maĺgorzata Milnerowicz
,
Cyril Dargazanli
,
Vincent Costalat
,
Isabelle Mourand
,
Caroline Arquizan
,
Lucas Corti
,
Ter Schiphorst
,
Cagnazzo Federico
,
Imad Derraz
,
Mehdi Mahmoudi
,
Pierre Henri Lefevre
,
Grégory Gascou
,
Laurent Spelle
,
Jildaz Caroff
,
Christian Denier
,
Vanessa Chalumeau
,
Cristian Mihalea
,
Augustin P. Ozanne
,
Léon Ikka
,
Olivier Chassin
,
Sophie Gallas
,
Laura Venditti
,
Jonathan Cortese
,
Jean Christophe Ferre
,
Stéphane Vannier
,
Thomas Ronziere
,
Maria Veronica Lassalle
,
Jean Yves Gauvrit
,
Clément Tracol
,
Abdelghani Fakhreddine Boustia
,
Cécile Malrain
,
Edouard Beaufreton
,
Thibaut Lapotre
,
Quentin Alias
,
Julien Hissier
,
Maud Guillen
,
François Eugene
,
Cyril Chivot
,
Audrey Courselle
,
Elisa Ouin
,
Chantal Lamy
,
Kévin Delaforge
,
Manuel Fernandez
,
Jérémie Vial
,
Quentin Laferte
,
Xavier Desdoit
,
Serge Timsit
(20)
,
Aurore Jourdain
,
Jean Christophe Gentric
,
J. Ognard
,
Irina Viakhireva
,
Jordan Coris
,
Sabine Prud'Hon
,
François Mathias Merrien
,
Denis Marechal
,
Marie Bruguet
,
Pierre Yves Rousseau
,
Philippe Goas
,
Marion Boulanger
,
Emmanuel Touze
,
Denis Vivien
,
Charlotte N. Barbier
,
Romain Schneckenburger
,
Fabrizio Salaris
,
Julien Cogez
,
Sophie Guettier
,
Estelle La Porte
,
Jean Bouchart
,
Charbel Mounayer
,
Aymeric M. Rouchaud
,
Suzana Saleme
,
Géraud Forestier
,
Frédéric Clarencon
,
Charlotte Rosso
,
Sara Julia Leder
,
Flore Baronnet
,
Sophie Crozier
,
Anne Leger
,
Kévin Premat
,
Shotar Eimad
,
Stéphanie Lenck
,
Nader Antoine Sourour
,
Laure Bottin
,
Sam Ghazanfari
,
Marion Yger
,
Sonia Alamowitch
,
Stephen Delorme
,
Aymeric Wittwer
,
Christine Vassilev
,
Olivier N. Naggara
,
G. Turc
,
Wagih Ben Hassen
,
Basile Kerleroux
,
Denis Trystram
,
Christine Rodriguez-Regent
,
Ozlem Ozkul-Wermester
,
Chrysanthi Papagiannaki
,
Evelyne Guégan Massardier
,
Aude Bagan Triquenot
,
Margaux Lefebvre
,
Julien Burel
,
Alain Viguier
,
Anne Christine Januel
,
Jean François Albucher
,
Lionel Calviere
,
Jean Darcourt
,
Fabrice Bonneville
,
Guillaume Bellanger
,
Philippe Tall
,
Claire Thalamas
,
Thomas Geerearts
,
Antoine Faurie Grepon
,
Frédéric D.Ric Bourdain
,
Patricia Bernady
,
Guillaume Ballan
,
Stéphanie Bannier
,
Emmanuel Ellie
,
Olivier Flabeau
,
Julia Potenza
,
Antoine Soulages
,
Laurent Lagoarde-Segot
,
Hélène Cailliez
,
David Higue
,
Louis Veunac
,
Anthony Lebras
,
Sarah Adam
,
Benoit Pegat
,
Arnaud Le Guen
,
François Chedeville
,
Jérémy Jouan
,
Stéphanie Demasles
,
Johann Sebastian Richter
,
Bruno Thierry Barroso
,
Camille Dahan
,
Alexis Gonnet
,
Régis Hubrecht
,
Zoé Lepine
,
Hélène Castagnet
,
Raluca Marasescu
,
Olivier Heck
,
Pauline Cuisenier
,
Olivier Detante
,
Isabelle Favre Wiki
,
Clémentine Bonaz
,
Katia Garambois
,
Loïc Legris
,
Adrian Kastler
,
Kamel Boubagra
,
Corentin Berthet
,
Stéphane Charara
,
Véronique Quenardelle
,
Valérie Lauer
,
Irène Nora Pierre-Paul
,
Malwina Trzeciak
,
Hua Vi Tuan
,
Paolo Pagano
,
Alexandre Doucet
,
Christophe Gelmini
,
Pierre François Manceau
,
Laurentiu Paiusan
,
Isabelle Serre
,
Thi Ngoc Phuong Nguyen
,
Maher Sahnoun
,
Nathalie Caucheteux
,
Anna Ferrier
,
Abderrahim Zerroug
,
Ricardo Moreno
,
Emmanuel Chabert
,
Elie Lteif
,
Nathalie Bourgois
,
Marie Raquin
,
Anne Pasco-Papon
,
Jean Baptiste Girot
,
Aldéric Lecluse
,
Sophie Godard
,
Vincent l'Allinec
,
Kévin Janot
,
Richard Edwige Bibi
,
Marie Gaudron
,
Arnaud Bretonniere
,
Mariam Annan
,
Héloïse Ifergan
,
Grégoire Boulouis
,
Marco Pasi
,
Séverine Debiais
,
Elisabeth Molinier
,
Anthony Wietrich
,
Valérie Ruche
,
Karine Lavandier
,
Yannick Bejot
,
Brivale Lemogne
,
Fédéric Ricolfi
,
Laura Baptiste
,
Pierre Thouant
,
Gauthier Duloquin
,
Pierre Olivier Comby
,
Guillaume Charbonnier
,
Louise Bonnet
,
Nicolas Raybaud
,
Benjamin Bouamra
,
T. Moulin
,
Alessandra Biondi
,
Nicolas Raposo
(8)
,
Jean-Marc Olivot
(9)
1
IADI -
Imagerie Adaptative Diagnostique et Interventionnelle
2 AHEPA University General Hospital [Thessaloniki]
3 CHU Rothschild [AP-HP]
4 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
5 Hôpital Foch [Suresnes]
6 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
7 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
8 Département Neurologie [CHU Toulouse]
9 ToNIC - Toulouse NeuroImaging Center
10 MSP - Mitochondrie, Stress oxydant et Protection musculaire
11 Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse]
12 CHU Reims - Hôpital universitaire Robert Debré [Reims]
13 UVSQ Santé - UFR Sciences de la santé Simone Veil
14 UNIMORE - Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia
15 ICM - Institut du Cerveau = Paris Brain Institute
16 NeuroDiderot (UMR_S_1141 / U1141) - Maladies neurodéveloppementales et neurovasculaires
17 Institut Bergonié [Bordeaux]
18 Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP]
19 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
20 GGB - Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)
2 AHEPA University General Hospital [Thessaloniki]
3 CHU Rothschild [AP-HP]
4 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
5 Hôpital Foch [Suresnes]
6 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
7 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
8 Département Neurologie [CHU Toulouse]
9 ToNIC - Toulouse NeuroImaging Center
10 MSP - Mitochondrie, Stress oxydant et Protection musculaire
11 Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse]
12 CHU Reims - Hôpital universitaire Robert Debré [Reims]
13 UVSQ Santé - UFR Sciences de la santé Simone Veil
14 UNIMORE - Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia
15 ICM - Institut du Cerveau = Paris Brain Institute
16 NeuroDiderot (UMR_S_1141 / U1141) - Maladies neurodéveloppementales et neurovasculaires
17 Institut Bergonié [Bordeaux]
18 Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP]
19 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
20 GGB - Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)
Stephanos Nikolaos Finitsis
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Mikael Mazighi
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Gaultier Marnat
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Śebastien Richard
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Tchikviladze Maia
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Georges L. Rodesch
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Michaël Alexandre Obadia
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Michel P. Piotin
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Stanislas J. Smajda
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Hocine Redjem
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Grace Adwan
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François Delvoye
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Amira Al Raaisi
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Tae-Hee Cho
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Laurent Derex
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Julia Fontaine
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Norbert Nighoghossian
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Lucie Rascle
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Mehdi Beyragued
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Yves Berthezene
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Marc R. Hermier
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Ameli Roxanna
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Alexandre Bani-Sadr
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Andrea Filip
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Matteo Cappucci
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Pierre Louis Alexandre
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Cédric Lenoble
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Solène De Gaalon
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Benoît Guillon
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Cécile Preterre
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Guillaume Tessier
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Arthur Lionnet
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Lisa Humbertjean-Selton
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René Anxionnat
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Anne Laure Derelle
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Liang Liao
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Emmanuelle Schmitt
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Sophie Planel
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Gioia Mione
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Jean Christophe Lacour
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Marian Douarinou
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Emilien Micard
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Bailiang Chen
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Gérard B. Audibert
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Agnès Masson
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Lionel Alb
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Marine Beaumont
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Adriana Tabarna
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Marcela Voicu
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Grégoire Barthel
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Iona Podar
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Madalina Brezeanu
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Marie Reitter
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François Zhu
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Jean Sébastien Liegey
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Pierre Briau
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Lisa Papillon
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Xavier Barreau
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Jean Papaxanthos
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Jerome Berge
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Sabrina Debruxelles
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Stéphane Olindo
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Mathilde Poli
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Pauline Renou
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Sharmila Sagnier
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Thomas Tourdias
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Thomas Courret
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Ludovic Lucas
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Maĺgorzata Milnerowicz
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Cyril Dargazanli
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Vincent Costalat
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Isabelle Mourand
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Caroline Arquizan
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Lucas Corti
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Ter Schiphorst
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Cagnazzo Federico
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Imad Derraz
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Mehdi Mahmoudi
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Pierre Henri Lefevre
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Grégory Gascou
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Laurent Spelle
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Jildaz Caroff
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Christian Denier
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Vanessa Chalumeau
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Cristian Mihalea
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Augustin P. Ozanne
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Léon Ikka
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Olivier Chassin
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Sophie Gallas
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Laura Venditti
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Jonathan Cortese
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Jean Christophe Ferre
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Stéphane Vannier
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Thomas Ronziere
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Maria Veronica Lassalle
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Jean Yves Gauvrit
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Clément Tracol
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Abdelghani Fakhreddine Boustia
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Cécile Malrain
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Edouard Beaufreton
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Thibaut Lapotre
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Quentin Alias
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Julien Hissier
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Maud Guillen
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François Eugene
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Cyril Chivot
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Audrey Courselle
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Chantal Lamy
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Kévin Delaforge
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Manuel Fernandez
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Jérémie Vial
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Quentin Laferte
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Xavier Desdoit
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Serge Timsit
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Aurore Jourdain
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Jean Christophe Gentric
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Irina Viakhireva
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Jordan Coris
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Sabine Prud'Hon
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François Mathias Merrien
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Denis Marechal
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Marie Bruguet
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Pierre Yves Rousseau
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Philippe Goas
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Marion Boulanger
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Emmanuel Touze
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Denis Vivien
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Charlotte N. Barbier
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Romain Schneckenburger
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Fabrizio Salaris
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Julien Cogez
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Sophie Guettier
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Estelle La Porte
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Jean Bouchart
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Charbel Mounayer
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Aymeric M. Rouchaud
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Suzana Saleme
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Géraud Forestier
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Frédéric Clarencon
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Charlotte Rosso
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Sara Julia Leder
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Flore Baronnet
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Sophie Crozier
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Anne Leger
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Kévin Premat
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Shotar Eimad
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Stéphanie Lenck
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Nader Antoine Sourour
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Laure Bottin
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Sam Ghazanfari
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Marion Yger
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Sonia Alamowitch
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Stephen Delorme
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Aymeric Wittwer
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Christine Vassilev
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G. Turc
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Wagih Ben Hassen
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Ozlem Ozkul-Wermester
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Aude Bagan Triquenot
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Margaux Lefebvre
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Anne Christine Januel
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Lionel Calviere
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Philippe Tall
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Claire Thalamas
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Thomas Geerearts
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Antoine Faurie Grepon
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Frédéric D.Ric Bourdain
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Patricia Bernady
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Guillaume Ballan
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Stéphanie Bannier
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Emmanuel Ellie
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Olivier Flabeau
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Julia Potenza
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Antoine Soulages
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Laurent Lagoarde-Segot
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Hélène Cailliez
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David Higue
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Louis Veunac
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Anthony Lebras
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Sarah Adam
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Benoit Pegat
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Arnaud Le Guen
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François Chedeville
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Jérémy Jouan
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Stéphanie Demasles
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Johann Sebastian Richter
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Bruno Thierry Barroso
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Camille Dahan
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Alexis Gonnet
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Régis Hubrecht
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Zoé Lepine
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Hélène Castagnet
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Raluca Marasescu
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Olivier Heck
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Pauline Cuisenier
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Olivier Detante
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Isabelle Favre Wiki
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Clémentine Bonaz
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Katia Garambois
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Loïc Legris
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Adrian Kastler
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Kamel Boubagra
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Corentin Berthet
- Function : Author
Stéphane Charara
- Function : Author
Véronique Quenardelle
- Function : Author
Valérie Lauer
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Irène Nora Pierre-Paul
- Function : Author
Malwina Trzeciak
- Function : Author
Hua Vi Tuan
- Function : Author
Paolo Pagano
- Function : Author
Alexandre Doucet
- Function : Author
Christophe Gelmini
- Function : Author
Pierre François Manceau
- Function : Author
Laurentiu Paiusan
- Function : Author
Isabelle Serre
- Function : Author
Thi Ngoc Phuong Nguyen
- Function : Author
Maher Sahnoun
- Function : Author
Nathalie Caucheteux
- Function : Author
Anna Ferrier
- Function : Author
Abderrahim Zerroug
- Function : Author
Ricardo Moreno
- Function : Author
Emmanuel Chabert
- Function : Author
Elie Lteif
- Function : Author
Nathalie Bourgois
- Function : Author
Marie Raquin
- Function : Author
Anne Pasco-Papon
- Function : Author
Jean Baptiste Girot
- Function : Author
Aldéric Lecluse
- Function : Author
Sophie Godard
- Function : Author
Vincent l'Allinec
- Function : Author
Kévin Janot
- Function : Author
Richard Edwige Bibi
- Function : Author
Marie Gaudron
- Function : Author
Arnaud Bretonniere
- Function : Author
Mariam Annan
- Function : Author
Héloïse Ifergan
- Function : Author
Grégoire Boulouis
- Function : Author
- PersonId : 1079563
- IdHAL : gregboul
- ORCID : 0000-0001-8422-9205
- IdRef : 160822246
Marco Pasi
- Function : Author
- PersonId : 1280167
- ORCID : 0000-0001-9976-2459
Séverine Debiais
- Function : Author
Elisabeth Molinier
- Function : Author
Anthony Wietrich
- Function : Author
Valérie Ruche
- Function : Author
Karine Lavandier
- Function : Author
Yannick Bejot
- Function : Author
- PersonId : 764168
- ORCID : 0000-0001-7848-7072
- IdRef : 13283491X
Brivale Lemogne
- Function : Author
Fédéric Ricolfi
- Function : Author
Laura Baptiste
- Function : Author
Pierre Thouant
- Function : Author
Gauthier Duloquin
- Function : Author
Pierre Olivier Comby
- Function : Author
Guillaume Charbonnier
- Function : Author
- PersonId : 1397924
- ORCID : 0000-0002-4425-3849
Louise Bonnet
- Function : Author
Nicolas Raybaud
- Function : Author
Benjamin Bouamra
- Function : Author
T. Moulin
- Function : Author
Alessandra Biondi
- Function : Author
Abstract
Background: Emergent stenting in tandem occlusions and mechanical thrombectomy (MT) of acute ischemic stroke related to large vessel occlusion (LVO-AIS) with a large core are tested independently. We aim to assess the impact of reperfusion with MT in patients with LVO-AIS with a large core and a tandem occlusion and to compare the safety of reperfusion between large core with tandem and nontandem occlusions in current practice. Methods: We analyzed data of all consecutive patients included in the prospective Endovascular Treatment in Ischemic Stroke Registry in France between January 2015 and March 2023 who presented with a pretreatment ASPECTS (Alberta Stroke Program Early CT Score) of 0–5 and angiographically proven tandem occlusion. The primary end point was a favorable outcome defined by a modified Rankin Scale (mRS) score of 0–3 at 90 days. Results: Among 262 included patients with a tandem occlusion and ASPECTS 0–5, 203 patients (77.5%) had a successful reperfusion (modified Thrombolysis in Cerebral Infarction grade 2b-3). Reperfused patients had a favorable shift in the overall mRS score distribution (adjusted odds ratio [aOR], 1.57 [1.22–2.03]; P < 0.001), higher rates of mRS score 0–3 (aOR, 7.03 [2.60–19.01]; P < 0.001) and mRS score 0–2 at 90 days (aOR, 3.85 [1.39–10.68]; P = 0.009) compared with nonreperfused. There was a trend between the occurrence of successful reperfusion and a decreased rate of symptomatic intracranial hemorrhage (aOR, 0.5 [0.22–1.13]; P = 0.096). Similar safety outcomes were observed after large core reperfusion in tandem and nontandem occlusions. Conclusions: Successful reperfusion was associated with a higher rate of favorable outcome in large core LVO-AIS with a tandem occlusion, with a safety profile similar to nontandem occlusion.
Domains
Life Sciences [q-bio]Origin | Files produced by the author(s) |
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