Global Incidence and Prevalence of Eosinophilic Esophagitis, 1976–2022: A Systematic Review and Meta-analysis - Archive ouverte HAL
Article Dans Une Revue Clinical Gastroenterology and Hepatology Année : 2023

Global Incidence and Prevalence of Eosinophilic Esophagitis, 1976–2022: A Systematic Review and Meta-analysis

Jong-Woo Hahn
  • Fonction : Auteur
Kwanjoo Lee
  • Fonction : Auteur
Jae-Il Shin
  • Fonction : Auteur
Seong-Ho Cho
  • Fonction : Auteur
Stephen William Turner
  • Fonction : Auteur
Jung U. Shin
  • Fonction : Auteur
Abdullah Özgür Yeniova
  • Fonction : Auteur
Ai Koyanagi
Lee Smith
Seung Won Lee
Rosie Kwon
  • Fonction : Auteur
Soeun Kim
  • Fonction : Auteur
Youn-Ho Shin
  • Fonction : Auteur
Sang Youl Rhee
Jin Soo Moon
Jae-Sung Ko
  • Fonction : Auteur
Dong Keon Yon
N. G. Papadopoulos

Résumé

Background and Aims: Owing to 2018 expanded diagnostic criteria for eosinophilic esophagitis (EoE) and thus a possible increase in diagnosis, previous studies on the global incidence and prevalence of EoE may need to be updated. We aimed to describe global, regional, and national trends in the incidence and prevalence of EoE from 1976 to 2022 and analyze their associations with geographic, demographic, and social factors through a systematic review. Methods: We searched the PubMed/MEDLINE, Embase, CINAHL, Google Scholar, and Cochrane databases from their inception dates to December 20, 2022, for studies that reported the incidence or prevalence of EoE in the general population. We calculated the global incidence and prevalence of EoE using pooled estimates with 95% confidence intervals (CIs) and performed subgroup analysis based on age, sex, race, geographical area, World Bank income group, and diagnostic criteria of EoE. Results: Forty studies met the eligibility criteria, including over 288 million participants and 147,668 patients with EoE from 15 countries across the five continents. The global pooled incidence and prevalence of EoE were 5.31 cases per 100,000 inhabitant-years (95% CI, 3.98–6.63; number of studies, 27; sample population, 42,191,506) and 40.04 cases per 100,000 inhabitant-years (95% CI, 31.10–48.98; number of studies, 20; sample population, 30,467,177), respectively. The pooled incidence of EoE was higher in high-income countries (vs low- or middle-income countries), males, and North America (vs Europe and Asia). The global prevalence of EoE followed a similar pattern. The pooled prevalence of EoE gradually increased from 1976 to 2022 (1976–2001; 8.18; 95% CI, 3.67–12.69 vs 2017–2022; 74.42; 95% CI, 39.66–109.19 cases per 100,000 inhabitant-years). Conclusions: The incidence and prevalence of EoE have increased substantially and vary widely across the world. Further research is needed to evaluate the incidence and prevalence of EoE in Asia, South America, and Africa.

Dates et versions

hal-04195016 , version 1 (04-09-2023)

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Jong-Woo Hahn, Kwanjoo Lee, Jae-Il Shin, Seong-Ho Cho, Stephen William Turner, et al.. Global Incidence and Prevalence of Eosinophilic Esophagitis, 1976–2022: A Systematic Review and Meta-analysis. Clinical Gastroenterology and Hepatology, 2023, ⟨10.1016/j.cgh.2023.06.005⟩. ⟨hal-04195016⟩
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