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Article Dans Une Revue Prostaglandins and Other Lipid Mediators Année : 2023

The effect of SARS-CoV-2 variants on the plasma oxylipins and PUFAs of COVID-19 patients

Denise Biagini

Résumé

Oxylipins are important signalling compounds that are significantly involved in the regulation of the immune system and the resolution of inflammation. Lipid metabolism is strongly activated upon SARS-CoV-2 infection, however the modulating effects of oxylipins induced by different variants remain unexplored. Here, we compare the plasma profiles of thirty-seven oxylipins and four PUFAs in subjects infected with Wild-type, Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529) variants. The results suggest that oxidative stress and inflammation resulting from COVID-19 were highly dependent on the SARS-CoV-2 variant, and that the Wild-type elicited the strongest inflammatory storm. The Alpha and Delta variants induced a comparable lipid profile alteration upon infection, which differed significantly from Omicron. The latter variant increased the levels of pro-inflammatory mediators and decreased the levels of omega-3 PUFA in infected patients. We speculate that changes in therapeutics, vaccination, and prior infections may have a role in the alteration of the oxylipin profile besides viral mutations. The results shed new light on the evolution of the inflammatory response in COVID-19.
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hal-04193908 , version 1 (10-10-2023)

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Denise Biagini, Paolo Oliveri, Andreina Baj, Daniela Dalla Gasperina, Francesca Drago Ferrante, et al.. The effect of SARS-CoV-2 variants on the plasma oxylipins and PUFAs of COVID-19 patients. Prostaglandins and Other Lipid Mediators, 2023, 169, pp.106770. ⟨10.1016/j.prostaglandins.2023.106770⟩. ⟨hal-04193908⟩
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