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Article Dans Une Revue eLife Année : 2021

Circuits for integrating learned and innate valences in the insect brain

Akira Fushiki
Michael Winding
Bruno Afonso
  • Fonction : Auteur
Ingrid Andrade
  • Fonction : Auteur
Benjamin Cocanougher
Katharina Eichler
Ruben Gepner
  • Fonction : Auteur
Guangwei Si
  • Fonction : Auteur
Javier Valdes-Aleman
  • Fonction : Auteur
Richard Fetter
Marc Gershow
Gregory Sxe Jefferis
Aravinthan Dt Samuel
James Truman
Albert Cardona
Marta Zlatic

Résumé

Animal behavior is shaped both by evolution and by individual experience. Parallel brain pathways encode innate and learned valences of cues, but the way in which they are integrated during action-selection is not well understood. We used electron microscopy to comprehensively map with synaptic resolution all neurons downstream of all mushroom body (MB) output neurons (encoding learned valences) and characterized their patterns of interaction with lateral horn (LH) neurons (encoding innate valences) in Drosophila larva. The connectome revealed multiple convergence neuron types that receive convergent MB and LH inputs. A subset of these receives excitatory input from positive-valence MB and LH pathways and inhibitory input from negative-valence MB pathways. We confirmed functional connectivity from LH and MB pathways and behavioral roles of two of these neurons. These neurons encode integrated odor value and bidirectionally regulate turning. Based on this, we speculate that learning could potentially skew the balance of excitation and inhibition onto these neurons and thereby modulate turning. Together, our study provides insights into the circuits that integrate learned and innate valences to modify behavior.
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hal-04193586 , version 1 (18-09-2023)

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Claire Eschbach, Akira Fushiki, Michael Winding, Bruno Afonso, Ingrid Andrade, et al.. Circuits for integrating learned and innate valences in the insect brain. eLife, 2021, 10, pp.10:e62567. ⟨10.7554/eLife.62567⟩. ⟨hal-04193586⟩
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