Risk factors for obesity in adulthood among survivors of childhood cancer
Laurène Delacourt
(1)
,
Rodrigue S. Allodji
(2, 3)
,
Juliette Chappat
(2, 3)
,
Nadia Haddy
(2, 3)
,
Chiraz El-Fayech
(3, 4)
,
Charlotte Demoor-Goldschmidt
(2, 5, 6)
,
Neige M.Y. Journy
(2, 3)
,
Stéphanie L.E. Bolle
(3)
,
Cécile Thomas-Teinturier
(7, 8)
,
Monia Zidane
(2, 3)
,
Carolé Rubino
(2, 3)
,
Cristina Veres
(2, 3)
,
Giao Vu-Bezin
(2, 3)
,
Delphine Berchery
(9)
,
Claire Pluchart
(10)
,
Pierre Yves Bondiau
(11)
,
Agnès Dumas
(7, 12)
,
Nicolas Bougas
(12)
,
Jacques Grill
(3, 4, 13)
,
Christelle Dufour
(3, 4)
,
Brice C. Fresneau
(7, 3, 4)
,
Hélène D. Pacquement
(1)
,
Ibrahima Diallo
(2)
,
François F. Doz
(12, 1)
,
Florent de Vathaire
(2, 3)
1
Institut Curie [Paris]
2 CESP - Centre de recherche en épidémiologie et santé des populations
3 IGR - Institut Gustave Roussy
4 Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy]
5 CHU Angers - Centre Hospitalier Universitaire d'Angers
6 Radiothérapie [Centre François Baclesse]
7 Université Paris-Saclay
8 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
9 Institut Claudius Regaud
10 CHU Reims - Hôpital universitaire Robert Debré [Reims]
11 UNICANCER/CAL - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice]
12 UPCité - Université Paris Cité
13 PMNCO - Prédicteurs moléculaires et nouvelles cibles en oncologie
2 CESP - Centre de recherche en épidémiologie et santé des populations
3 IGR - Institut Gustave Roussy
4 Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy]
5 CHU Angers - Centre Hospitalier Universitaire d'Angers
6 Radiothérapie [Centre François Baclesse]
7 Université Paris-Saclay
8 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
9 Institut Claudius Regaud
10 CHU Reims - Hôpital universitaire Robert Debré [Reims]
11 UNICANCER/CAL - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice]
12 UPCité - Université Paris Cité
13 PMNCO - Prédicteurs moléculaires et nouvelles cibles en oncologie
Rodrigue S. Allodji
- Fonction : Auteur
- PersonId : 4839
- IdHAL : rodrigue-setcheou-allodji
- ORCID : 0000-0002-1895-8415
Agnès Dumas
- Fonction : Auteur
- PersonId : 4422
- IdHAL : agnes-dumas
- ORCID : 0000-0001-7948-6952
- IdRef : 158640462
Brice C. Fresneau
- Fonction : Auteur
- PersonId : 1199184
- IdHAL : b-fresneau
- ORCID : 0000-0001-7603-7828
Florent de Vathaire
- Fonction : Auteur
- PersonId : 1162629
- IdHAL : florent-de-vathaire
- ORCID : 0000-0002-8374-9281
Résumé
Objective: The aim of this study was to identify risk factors for obesity in childhood cancer survivors (CCSs). Methods: The study included 3199 patients of the French Childhood Cancer Survivor Study cohort, with 303 patients with obesity who had returned the self-questionnaire. Analyses were adjusted for social deprivation index and sex. Results: CCSs were less likely to have obesity (9.5%; 95% CI: 8.5%–10.5%) than expected from the general French population rates (12.5%; p = 0.0001). Nevertheless, brain tumor survivors were significantly more likely to develop obesity than the general French population (p = 0.0001). Compared with patients who did not receive radiotherapy to the pituitary gland, those who received a dose >5 Gy had an increased risk of obesity: relative risk 1.9 (95% CI: 1.2–3.1), 2.5 (95% CI: 1.7–3.7), and 2.6 (95% CI: 1.6–4.3), respectively, for participants with 6 to 20 Gy, 20 to 40 Gy, and ≥40 Gy of radiation. Etoposide administration significantly increased the risk of obesity (relative risk 1.7; 95% CI: 1.1–2.6). High social deprivation index was also a risk factor, just like BMI at diagnosis. Conclusions: Long-term follow-up of CCSs should include weight follow-up during adulthood.