No changes in clinical presentation, treatment strategies and survival of pancreatic cancer cases during the SARS‐COV‐2 outbreak: A retrospective multicenter cohort study on real‐world data - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Cancer Année : 2023

No changes in clinical presentation, treatment strategies and survival of pancreatic cancer cases during the SARS‐COV‐2 outbreak: A retrospective multicenter cohort study on real‐world data

Résumé

The SARS-COV-2 pandemic disrupted healthcare systems. We assessed its impact on the presentation, care trajectories and outcomes of new pancreatic cancers (PCs) in the Paris area. We performed a retrospective multicenter cohort study on the data warehouse of Greater Paris University Hospitals (AP-HP). We identified all patients newly referred with a PC between January 1, 2019, and June 30, 2021, and excluded endocrine tumors. Using claims data and health records, we analyzed the timeline of care trajectories, the initial tumor stage, the treatment categories: pancreatectomy, exclusive systemic therapy or exclusive best supportive care (BSC). We calculated patients' 1-year overall survival (OS) and compared indicators in 2019 and 2020 to 2021. We included 2335 patients. Referral fell by 29% during the first lockdown. The median time from biopsy and from first MDM to treatment were 25 days (16-50) and 21 days (11-40), respectively. Between 2019 and 2020 to 2021, the rate of metastatic tumors (36% vs 33%, P = .39), the pTNM distribution of the 464 cases with upfront tumor resection (P = .80), and the proportion of treatment categories did not vary: tumor resection (32% vs 33%), exclusive systemic therapy (49% vs 49%), exclusive BSC (19% vs 19%). The 1-year OS rates in 2019 vs 2020 to 2021 were 92% vs 89% (aHR = 1.42; 95% CI, 0.82-2.48), 52% vs 56% (aHR = 0.88; 95% CI, 0.73-1.08), 13% vs 10% (aHR = 1.00; 95% CI, 0.78-1.25), in the treatment categories, respectively. Despite an initial decrease in the number of new PCs, we did not observe any stage shift. OS did not vary significantly.
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Dates et versions

hal-04189069 , version 1 (28-08-2023)

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Emmanuelle Kempf, Sonia Priou, Guillaume Lamé, Alexis Laurent, Etienne Guével, et al.. No changes in clinical presentation, treatment strategies and survival of pancreatic cancer cases during the SARS‐COV‐2 outbreak: A retrospective multicenter cohort study on real‐world data. International Journal of Cancer, 2023, 153 (12), pp.1988-1996. ⟨10.1002/ijc.34675⟩. ⟨hal-04189069⟩
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