Apparent Absence of Selective Pressure on Pneumocystis jirovecii Organisms in Patients with Prior Methotrexate Exposure - Archive ouverte HAL
Article Dans Une Revue (Data Paper) Antimicrobial Agents and Chemotherapy Année : 2022

Apparent Absence of Selective Pressure on Pneumocystis jirovecii Organisms in Patients with Prior Methotrexate Exposure

Résumé

Pneumocystis jirovecii infections occur in patients treated with methotrexate (MTX) because of immunosuppressive effects of this highly potent dihydrofolate reductase (DHFR) inhibitor. Conversely, MTX may act as an anti -P. jirovecii drug and consequently may exert a selective pressure on this fungus.
Fichier principal
Vignette du fichier
Bonnet, AAC, 2022_DHFR-MTX.pdf (229.8 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04301221 , version 1 (22-11-2023)

Identifiants

Citer

Pierre L Bonnet, Solène Le Gal, Chloé Gautier, Claire V Hoffmann, Nathan Le Nan, et al.. Apparent Absence of Selective Pressure on Pneumocystis jirovecii Organisms in Patients with Prior Methotrexate Exposure. Antimicrobial Agents and Chemotherapy, 2022, 66 (12), ⟨10.1128/aac.00990-22⟩. ⟨hal-04301221⟩
22 Consultations
35 Téléchargements

Altmetric

Partager

More