<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04186707</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T04:03:30+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Polysaccharides, proteins, and synthetic polymers based multimodal hydrogels for various biomedical applications: A review</title>
            <author role="aut">
              <persName>
                <forename type="first">Anuj</forename>
                <surname>Kumar</surname>
              </persName>
              <idno type="halauthorid">963547-0</idno>
              <affiliation ref="#struct-466055"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ankur</forename>
                <surname>Sood</surname>
              </persName>
              <idno type="halauthorid">2684189-0</idno>
              <affiliation ref="#struct-466055"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Garima</forename>
                <surname>Agrawal</surname>
              </persName>
              <idno type="halauthorid">2881688-0</idno>
              <affiliation ref="#struct-535447"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sourbh</forename>
                <surname>Thakur</surname>
              </persName>
              <idno type="halauthorid">2881689-0</idno>
              <affiliation ref="#struct-140309"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vijay Kumar</forename>
                <surname>Thakur</surname>
              </persName>
              <idno type="halauthorid">2117433-0</idno>
              <affiliation ref="#struct-361086"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Masaru</forename>
                <surname>Tanaka</surname>
              </persName>
              <idno type="halauthorid">2535340-0</idno>
              <affiliation ref="#struct-488517"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yogendra Kumar</forename>
                <surname>Mishra</surname>
              </persName>
              <idno type="halauthorid">1983145-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Graham</forename>
                <surname>Christie</surname>
              </persName>
              <idno type="halauthorid">2881690-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ebrahim</forename>
                <surname>Mostafavi</surname>
              </persName>
              <idno type="halauthorid">997793-0</idno>
              <affiliation ref="#struct-524472"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Rabah</forename>
                <surname>Boukherroub</surname>
              </persName>
              <email type="md5">767e5971961f5d0c5b917a97e5ed0437</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="string">rabah-boukherroub</idno>
              <idno type="idhal" notation="numeric">177969</idno>
              <idno type="halauthorid" notation="string">45105-177969</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9795-9888</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.com/citations?user=ouWAEXAAAAAJ&amp;hl=fr</idno>
              <idno type="IDREF">https://www.idref.fr/139279474</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=ouWAEXAAAAAJ</idno>
              <affiliation ref="#struct-1066983"/>
              <affiliation ref="#struct-1067477"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dietmar</forename>
                <surname>Hutmacher</surname>
              </persName>
              <idno type="halauthorid">365776-0</idno>
              <affiliation ref="#struct-301111"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Sung Soo</forename>
                <surname>Han</surname>
              </persName>
              <email type="md5">aeed6f34298da3e992cb60d8967b2f51</email>
              <email type="domain">yu.ac.kr</email>
              <idno type="idhal" notation="numeric">1277245</idno>
              <idno type="halauthorid" notation="string">2684191-1277245</idno>
              <affiliation ref="#struct-466055"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Accord Elsevier</forename>
                <surname>CCSD</surname>
              </persName>
              <email type="md5">3cc0cc7b8e3329bfb7423fa2578d788e</email>
              <email type="domain">ccsd.cnrs.fr</email>
            </editor>
            <funder>This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (Grant No. 2021R1I1A3059994 and 2020K1A3A1A19088873). Also, A.K. acknowledges the Ramalingaswami Re-entry Fellowship (Ref: BT/HRD/35/02/2006) of Department of Biotechnology, Government of India.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-10-01 14:11:42</date>
              <date type="whenModified">2026-03-23 09:10:02</date>
              <date type="whenReleased">2025-10-01 14:11:43</date>
              <date type="whenProduced">2023-08</date>
              <date type="whenEndEmbargoed">2024-07-14</date>
              <ref type="file" target="https://hal.science/hal-04186707v1/document">
                <date notBefore="2024-07-14"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-04186707v1/file/S014181302302500X.pdf" id="file-5291874-4534709">
                <date notBefore="2024-07-14"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1081876">
                <persName>
                  <forename>Accord Elsevier</forename>
                  <surname>CCSD</surname>
                </persName>
                <email type="md5">3cc0cc7b8e3329bfb7423fa2578d788e</email>
                <email type="domain">ccsd.cnrs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04186707</idno>
            <idno type="halUri">https://hal.science/hal-04186707</idno>
            <idno type="halBibtex">kumar:hal-04186707</idno>
            <idno type="halRefHtml">&lt;i&gt;International Journal of Biological Macromolecules&lt;/i&gt;, 2023, 247, pp.125606. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.ijbiomac.2023.125606"&gt;&amp;#x27E8;10.1016/j.ijbiomac.2023.125606&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">International Journal of Biological Macromolecules, 2023, 247, pp.125606. &amp;#x27E8;10.1016/j.ijbiomac.2023.125606&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc/4.0/">CC BY-NC 4.0 - Attribution - Non-commercial use<ref corresp="#file-5291874-4534709"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-VALENCIENNES">Université de Valenciennes et du Hainaut-Cambresis</idno>
            <idno type="stamp" n="IEMN">Institut d'électronique, de microélectronique et de nanotechnologie</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
            <idno type="stamp" n="ELSEVIER">Import Elsevier</idno>
            <idno type="stamp" n="UNIV-CATHOLILLE">Université catholique de Lille</idno>
            <idno type="stamp" n="TEST-UPHF">TEST-UPHF</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Polysaccharides, proteins, and synthetic polymers based multimodal hydrogels for various biomedical applications: A review</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Anuj</forename>
                    <surname>Kumar</surname>
                  </persName>
                  <idno type="halauthorid">963547-0</idno>
                  <affiliation ref="#struct-466055"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ankur</forename>
                    <surname>Sood</surname>
                  </persName>
                  <idno type="halauthorid">2684189-0</idno>
                  <affiliation ref="#struct-466055"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Garima</forename>
                    <surname>Agrawal</surname>
                  </persName>
                  <idno type="halauthorid">2881688-0</idno>
                  <affiliation ref="#struct-535447"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sourbh</forename>
                    <surname>Thakur</surname>
                  </persName>
                  <idno type="halauthorid">2881689-0</idno>
                  <affiliation ref="#struct-140309"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vijay Kumar</forename>
                    <surname>Thakur</surname>
                  </persName>
                  <idno type="halauthorid">2117433-0</idno>
                  <affiliation ref="#struct-361086"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Masaru</forename>
                    <surname>Tanaka</surname>
                  </persName>
                  <idno type="halauthorid">2535340-0</idno>
                  <affiliation ref="#struct-488517"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yogendra Kumar</forename>
                    <surname>Mishra</surname>
                  </persName>
                  <idno type="halauthorid">1983145-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Graham</forename>
                    <surname>Christie</surname>
                  </persName>
                  <idno type="halauthorid">2881690-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ebrahim</forename>
                    <surname>Mostafavi</surname>
                  </persName>
                  <idno type="halauthorid">997793-0</idno>
                  <affiliation ref="#struct-524472"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Rabah</forename>
                    <surname>Boukherroub</surname>
                  </persName>
                  <email type="md5">767e5971961f5d0c5b917a97e5ed0437</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="string">rabah-boukherroub</idno>
                  <idno type="idhal" notation="numeric">177969</idno>
                  <idno type="halauthorid" notation="string">45105-177969</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9795-9888</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.com/citations?user=ouWAEXAAAAAJ&amp;hl=fr</idno>
                  <idno type="IDREF">https://www.idref.fr/139279474</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=ouWAEXAAAAAJ</idno>
                  <affiliation ref="#struct-1066983"/>
                  <affiliation ref="#struct-1067477"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dietmar</forename>
                    <surname>Hutmacher</surname>
                  </persName>
                  <idno type="halauthorid">365776-0</idno>
                  <affiliation ref="#struct-301111"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Sung Soo</forename>
                    <surname>Han</surname>
                  </persName>
                  <email type="md5">aeed6f34298da3e992cb60d8967b2f51</email>
                  <email type="domain">yu.ac.kr</email>
                  <idno type="idhal" notation="numeric">1277245</idno>
                  <idno type="halauthorid" notation="string">2684191-1277245</idno>
                  <affiliation ref="#struct-466055"/>
                </author>
              </analytic>
              <monogr>
                <idno type="localRef">flagship_health</idno>
                <idno type="halJournalId" status="VALID">11429</idno>
                <idno type="issn">0141-8130</idno>
                <title level="j">International Journal of Biological Macromolecules</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">247</biblScope>
                  <biblScope unit="pp">125606</biblScope>
                  <date type="datePub">2023-08</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.ijbiomac.2023.125606</idno>
              <idno type="pii">S0141-8130(23)02500-X</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Biomaterials</term>
                <term xml:lang="en">Polysaccharides</term>
                <term xml:lang="en">Hydrogels</term>
              </keywords>
              <classCode scheme="halDomain" n="phys">Physics [physics]</classCode>
              <classCode scheme="halDomain" n="spi">Engineering Sciences [physics]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART.ARTREV">Journal articles - Review article</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Nature-derived or biologically encouraged hydrogels have attracted considerable interest in numerous biomedical applications owing to their multidimensional utility and effectiveness. The internal architecture of a hydrogel network, the chemistry of the raw materials involved, interaction across the interface of counter ions, and the ability to mimic the extracellular matrix (ECM) govern the clinical efficacy of the designed hydrogels. This review focuses on the mechanistic viewpoint of different biologically driven/inspired biomacromolecules that encourages the architectural development of hydrogel networks. In addition, the advantage of hydrogels by mimicking the ECM and the significance of the raw material selection as an indicator of bioinertness is deeply elaborated in the review. Furthermore, the article reviews and describes the application of polysaccharides, proteins, and synthetic polymer-based multimodal hydrogels inspired by or derived from nature in different biomedical areas. The review discusses the challenges and opportunities in biomaterials along with future prospects in terms of their applications in biodevices or functional components for human health issues. This review provides information on the strategy and inspiration from nature that can be used to develop a link between multimodal hydrogels as the main frame and its utility in biomedical applications as the primary target.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-466055" status="VALID">
          <orgName>Yeungnam University [South Korea]</orgName>
          <date type="start">2016-09-15</date>
          <desc>
            <address>
              <addrLine>214-1 Daedong Gyoungsan 712-749</addrLine>
              <country key="KR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-535447" status="VALID">
          <idno type="ROR">https://ror.org/05r9r2f34</idno>
          <orgName>Indian Institute of Technology Mandi</orgName>
          <orgName type="acronym">IIT Mandi</orgName>
          <desc>
            <address>
              <addrLine>Kamand Campus, VPO Kamand,Distt. Mandi - 175005 Himachal PradeshIndia</addrLine>
              <country key="IN"/>
            </address>
            <ref type="url">http://www.iitmandi.ac.in/index.html</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-140309" status="VALID">
          <idno type="ROR">https://ror.org/02dyjk442</idno>
          <orgName>Silesian University of Technology</orgName>
          <desc>
            <address>
              <addrLine>ul. Akademicka 2A, 44-100 Gliwice</addrLine>
              <country key="PL"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-361086" status="VALID">
          <idno type="ROR">https://ror.org/044e2ja82</idno>
          <orgName>Scotland's Rural College</orgName>
          <orgName type="acronym">SRUC</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Craibstone Estate, Ferguson Building, Aberdeen AB21 9YA</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">https://www.sruc.ac.uk</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-488517" status="VALID">
          <orgName>Tokyo Women's Medical University</orgName>
          <orgName type="acronym">TWMU</orgName>
          <desc>
            <address>
              <addrLine>8-1, Kawada-cho, Shinjuku-ku, Tokyo</addrLine>
              <country key="JP"/>
            </address>
            <ref type="url">http://www.twmu.ac.jp/english/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-524472" status="VALID">
          <orgName>Stanford Cardiovascular Institute</orgName>
          <desc>
            <address>
              <addrLine>Stanford University, Stanford, CA 94305</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">http://med.stanford.edu/cvi.html</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1066983" status="VALID">
          <idno type="IdRef">138736421</idno>
          <idno type="ISNI">0000000403683863</idno>
          <idno type="RNSR">199812849E</idno>
          <idno type="ROR">https://ror.org/02q4res37</idno>
          <idno type="Wikidata">Q3151942</idno>
          <orgName>Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520</orgName>
          <orgName type="acronym">IEMN</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>[Univ. Lille, CNRS, Centrale Lille Institut, Junia, Univ. Polytechnique Hauts-de-France] ––Laboratoire Central – Cité Scientifique – Avenue Poincaré – CS 60069 – 59652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.iemn.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-120930" type="direct"/>
            <relation active="#struct-374570" type="direct"/>
            <relation name="UMR8520" active="#struct-441569" type="direct"/>
            <relation active="#struct-1001263" type="direct"/>
            <relation active="#struct-1059196" type="direct"/>
            <relation active="#struct-300877" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1067477" status="VALID">
          <idno type="RNSR">199223915J</idno>
          <orgName>NanoBioInterfaces - IEMN</orgName>
          <orgName type="acronym">NBI - IEMN</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Groupe NBI - CCHB IRCICA - 50 Avenue Halley - 59650 Villeneuve d'Ascq</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.iemn.fr/la-recherche/les-groupes/groupe-nbi</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1066983" type="direct"/>
            <relation active="#struct-120930" type="indirect"/>
            <relation active="#struct-374570" type="indirect"/>
            <relation name="UMR8520" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1001263" type="indirect"/>
            <relation active="#struct-1059196" type="indirect"/>
            <relation active="#struct-300877" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301111" status="VALID">
          <idno type="ROR">https://ror.org/01tgyzw49</idno>
          <orgName>National University of Singapore</orgName>
          <orgName type="acronym">NUS</orgName>
          <desc>
            <address>
              <addrLine>21 Lower Kent Ridge Rd, Singapour 119077</addrLine>
              <country key="SG"/>
            </address>
            <ref type="url">http://www.nus.edu.sg/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-120930" status="VALID">
          <idno type="IdRef">256304629</idno>
          <idno type="ISNI">0000000122034461</idno>
          <idno type="ROR">https://ror.org/01x441g73</idno>
          <orgName>Centrale Lille</orgName>
          <desc>
            <address>
              <addrLine>École Centrale de Lille - Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://centralelille.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-374570" status="VALID">
          <idno type="IdRef">223446556</idno>
          <idno type="ISNI">0000 0001 2242 6780</idno>
          <idno type="ROR">https://ror.org/02kzqn938</idno>
          <idno type="Wikidata">Q3551621</idno>
          <orgName>Université de Lille</orgName>
          <desc>
            <address>
              <addrLine>EPE Université de Lille. -- 42 rue Paul Duez, 59000 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1001263" status="VALID">
          <idno type="IdRef">242335675</idno>
          <idno type="ROR">https://ror.org/02ezch769</idno>
          <orgName>Université Polytechnique Hauts-de-France</orgName>
          <orgName type="acronym">UPHF</orgName>
          <date type="start">2019-09-09</date>
          <desc>
            <address>
              <addrLine>Campus Mont Houy59313 Valenciennes Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.uphf.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1059196" status="VALID">
          <idno type="IdRef">258598026</idno>
          <idno type="ROR">https://ror.org/02evec030</idno>
          <orgName>JUNIA</orgName>
          <orgName type="acronym">JUNIA</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>2 Rue Norbert Segard59014 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.junia.com/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300877" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300877" status="VALID">
          <idno type="IdRef">026582481</idno>
          <idno type="ROR">https://ror.org/025s1b152</idno>
          <orgName>Université catholique de Lille</orgName>
          <orgName type="acronym">UCL</orgName>
          <desc>
            <address>
              <addrLine>60 boulevard Vauban - 59800 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-catholille.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>